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      Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

      Science

      American Association for the Advancement of Science (AAAS)

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          Abstract

          In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

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          Author and article information

          Journal
          Science
          American Association for the Advancement of Science (AAAS)
          00368075
          10959203
          September 7 2001
          : 293
          : 5536
          : 1840-1842
          Article
          10.1126/science.1062882
          11546875
          81eca19b-58a9-43a4-955c-20aad68643da
          © 2001

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