The behavior of the uncertainty relations and their tightness for a system, consisting of two qubits interacting thermally with a magnetic field in the presence of Dzyaloshinskii–Moriya interaction, is discussed, where different types of interaction strengths are considered. It is shown that both coupling and the magnetic field parameters decay the degree of entanglement, and increasing the uncertainty relations and the degree of mixedness. The phenomena of the sudden changes in the investigated quantities are depicted at large values of the field and coupling parameters. Concerning the type of the coupling parameters, distance and the trigonometric coupling have a clear effect on the behavior of the studied physical quantities.