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      Epstein–Barr virus-associated nephrotic syndrome

      case-report

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          Abstract

          Acute infection with Epstein–Barr virus (EBV) causes fever, fatigue and pharyngitis. Renal involvement in systemic EBV infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. Rarely, EBV infection causes nephrotic syndrome due to minimal change disease. A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome. Renal biopsy showed minimal change disease with diffuse foot process effacement of the podocytes. Treatment with methylprednisone led to rapid and complete clinical remission. Minimal change nephropathy is a very rare manifestation of EBV infection and should be considered in patients with IM and proteinuria.

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          Infectious mononucleosis.

          Katherine Luzuriaga, John Sullivan (2010)
          Article 0 comments Cited 159 times – based on 0 reviews     Review now
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            Epstein-Barr virus-induced infectious mononucleosis complicated by acute renal failure: case report and review.

            J. Williams, Monica Hammer, A W Crosson … (1996)
            Infectious mononucleosis, most commonly caused by Epstein-Barr virus (EBV), is generally a benign, self-limited illness. Occasionally, however, more severe complications may arise such as acute renal insufficiency. While subclinical renal involvement appears to be relatively common in patients with infectious mononucleosis, patients with significant renal parenchymal dysfunction have rarely been described in the English-language literature. In this report, we review 27 previous cases ad present a case of oliguric renal failure complicating heterophil-positive infectious mononucleosis. The patient required hemodialysis but recovered promptly with treatment with the combination of corticosteroids plus acyclovir. Renal biopsy revealed interstitial nephritis, and immunoperoxidase studies demonstrated a predominance of suppressor/cytotoxic T cells, which has been described in only one previous case report. In situ hybridization done on renal biopsy tissue failed to reveal evidence of EBV-encoded RNA-1. Acute renal failure in infectious mononucleosis is rare, often self-limited, and usually caused by interstitial nephritis that is likely the result of immunopathologic injury precipitated by EBV infection.
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              Acute renal failure: unusual complication of Epstein-Barr virus-induced infectious mononucleosis.

              P Lei, W. Allen, T J Mauch … (2000)
              A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.
              Article 0 comments Cited 6 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clin Kidney J
                Journal ID (iso-abbrev): Clin Kidney J
                Journal ID (hwp): ndtplus
                Journal ID (publisher-id): ckj
                Title: Clinical Kidney Journal
                Publisher: Oxford University Press
                ISSN (Print): 2048-8505
                ISSN (Electronic): 2048-8513
                Publication date (Print): February 2012
                Publication date PMC-release: February 2012
                Volume: 5
                Issue: 1
                Pages: 50-52
                Affiliations
                [1 ]Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
                [2 ]Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
                [3 ]Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
                Author notes
                Correspondence and offprint requests to: Marie C. Hogan; E-mail: hogan.marie@ 123456mayo.edu
                Article
                DOI: 10.1093/ndtplus/sfr119
                PMC ID: 4400449
                SO-VID: 820d311b-55de-43fd-a92a-cf25760eafd7
                Copyright © © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                Date received : 27 July 2011
                Date accepted : 24 August 2011
                Page count
                Pages: 3
                Categories
                Subject: Clinical Cases
                Subject: Clinical Reports

                ScienceOpen disciplines: Nephrology
                Keywords: infectious mononucleosis,minimal change disease,nephrotic syndrome
                Data availability:
                ScienceOpen disciplines: Nephrology
                Keywords: infectious mononucleosis, minimal change disease, nephrotic syndrome

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