35
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      El Desodorante Antitranspirante y su Efecto Arritmogénico por Acción del Aluminio: Experiencia Clínica y Electrocardiográfica en 1.500 Pacientes

      research-article

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Un efecto patógeno del aluminio presente en todos los desodorantes antitranspirantes en cualquiera de sus presentaciones, desconocido hasta el presente, es el de producir arritmias cardíacas, el cual demostramos clínica y electrocardiográficamente en este trabajo. Este producto de uso generalizado produce extrasístoles ventriculares esenciales (latidos prematuros) debido a la posible acción de las sales de aluminio (clorhidrato, sulfato y otras), de acción constrictora sobre el músculo liso, incluyendo los contenidos en los vasos arteriales y en el folículo piloso, entre otros. En estudio de 1,500 casos de extrasistolia ventricular esencial, se demuestra que la omisión de los desodorantes que contienen aluminio, que son todos los procesados industrialmente en todas sus presentaciones, constituye una de sus principales causas. La omisión de dichos productos como única medida, produjo la desaparición de la arritmia en el 76 por ciento de los casos, y agregando uno o dos antiarrítmicos a baja dosis en el 24 por ciento restante. Los resultados favorables encontrados sucedieron un mes después del inicio del tratamiento, y se mantuvieron hasta los seis meses en el 100 por ciento de ellos, únicamente evitando el desodorante industrializado. El mecanismo de acción de este efecto benéfico no se conoce, por lo cual se ameritan nuevas investigaciones experimentales para determinarlo y para determinar si también estos productos tan difundidos tienen inherencia en la génesis de la hipertensión arterial.

          Translated abstract

          Aluminum is a metal present in most of commercial deodorants as a soluble salt. Apparently, this element is able to produce a wide range of cardiovascular effects like high blood pressure and premature ventricular beats. The aim of this study was to examine 1.500 consecutive patients with clinical and EKG diagnosis of idiopathic premature ventricular beats and the effect of the abolition of such abnormalities with the medical intervention that consisted in: a. omission of the aluminum containing deodorant. B. An antiarrhytmic drug and deodorant omission and c. two antiarrhytmic drugs and deodorant omission. All patient were users of aluminum contained deodorants and did not have any other pathology that could explain this cardiovascular manifestation. Only the cessation the use of deodorants containing aluminum caused a dramatic disappearance of premature ventricular beats in 1.140 patients (76 %). Three hundred patients (20 %) received an antiarrhytmic drug plus deodorant omission and only sixty patients (4%) need two antiarrhytmic drug plus deodorant cessation in order problem. After one month of treatren persist six runths after (end uf the follow -up). The mechanism of action of this effect remains unknown. Further studies must be done in order to dilucidate the role of aluminum and related elements in high blood pressure genesis and oxidative stress related disorders.

          Related collections

          Most cited references25

          • Record: found
          • Abstract: not found
          • Article: not found

          Free radicals, antioxidants, and human disease: where are we now?

            • Record: found
            • Abstract: found
            • Article: not found

            Aluminum toxicity in patients with chronic renal failure.

            A Alfrey (1993)
            During the past two decades, in association with the commencement of chronic dialysis therapy and prolongation of the uremic state, aluminum toxicity has represented a major cause of morbidity and mortality in uremic patients. The uremic patient has been found to be at higher risk of aluminum loading and toxicity from various sources of parenteral exposure, enhanced gastrointestinal absorption, and compromised ability to eliminate any systemically administered aluminum due to renal impairment. However, the potential sources of aluminum exposure and loading resulting in toxicity in uremic patients have recently been identified. As a result, this toxicity can largely be prevented by eliminating aluminum from the water used to prepare the dialysate, substituting calcium-containing phosphate-binding agents for those containing aluminum, and strict avoidance of the concomitant use of citrate- and aluminum-containing compounds. Thus, in the future, aluminum toxicity should represent a rare and unusual side effect in dialyzed uremic patients.
              • Record: found
              • Abstract: not found
              • Article: not found

              Electrocardiografía diagnóstica

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                avft
                Archivos Venezolanos de Farmacología y Terapéutica
                AVFT
                Sociedad Venezolana de Farmacológia y Farmacológia Clínica y Terapéutica. Escuela de Medicina (Caracas )
                0798-0264
                July 2000
                : 19
                : 2
                : 117-120
                Affiliations
                [1 ] Universidad del Zulia
                Article
                S0798-02642000000200008
                82130152-bd63-44d2-92d3-0a6f684f4423

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Venezuela

                Self URI (journal page): http://www.scielo.org.ve/scielo.php?script=sci_serial&pid=0798-0264&lng=en
                Categories
                PHARMACOLOGY & PHARMACY

                Pharmacology & Pharmaceutical medicine
                Deodorants,Aluminum,Ventricular Extrasistolia,Entiarrhytmic,Blood vasocontrictive,Desodorante antisudoral,Aluminio,Extrasistolia ventricular,Antiarrítmicos,Vasoconstricción arterial

                Comments

                Comment on this article

                Related Documents Log