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      Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

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          Abstract

          A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Sep 13 1990
          : 347
          : 6289
          Affiliations
          [1 ] Unité de Neurobiologie et Pharmacologie (U. 109) de l'INSERM, Paris, France.
          Article
          10.1038/347146a0
          1975644
          821da233-f0cd-4034-811b-c5f6e2fd97f1
          History

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