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      Effects of Sex Hormones on the Passive Mechanical Properties of Rat Carotid Artery

      Journal of Vascular Research
      S. Karger AG
      Arterial wall mechanics, Incremental elastic modulus, Collagen, Elastin

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          The effects of chronic administration of estradiol and testosterone on the passive mechanical properties of carotid arteries were determined using castrated and noncastrated male rats. Blood vessel segments were removed from the animals and mounted in a bath at in vivo length. Measurements of external diameter and transmural pressure were made in response to inflation in the presence of smooth muscle inhibitors. These data were used to determine stress-strain relations and values of incremental elastic moduli for the various arteries. Relative to arteries from control animals, passive tangential stress-strain curves for arteries from estradiol treated rats were found to be shifted significantly to the right, i.e., to larger strains. Similar data for testosterone-treated arteries were shifted to the left, but the effect was smaller than the former one and only significant for values of tangential stress greater than 2 × 10<sup>–6</sup> dyn/cm<sup>2</sup>. At specific values of wall strain, estradiol produced a decrease in incremental elastic modulus relative to the arteries from control animals, while testosterone produced an increase in elastic modulus which was only significant for strains > 0.7. Quantitatively, similar results were found in castrated and noncastrated rats. These results are consistent with the concepts that estradiol decreases the stiffness of arteries while testosterone to a smaller degree increases the latter through the effects of these steroids on connective tissue accumulation in the arterial wall.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 15
          : 4
          : 266-276
          Bockus Institute and Department of Physiology, University of Pennsylvania, Philadelphia, Pa.
          158172 Blood Vessels 1978;15:266–276
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 01 February 1977
          : 08 July 1977
          Page count
          Pages: 11

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Collagen,Elastin,Arterial wall mechanics,Incremental elastic modulus


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