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Hydrogels in pharmaceutical formulations.

European Journal of Pharmaceutics and Biopharmaceutics

Physicochemical Phenomena, Animals, Chemistry, Pharmaceutical, Chemistry, Physical, Drug Delivery Systems, Humans, Hydrogels, chemistry, Pharmacokinetics

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      Abstract

      The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

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