TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways.

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Abstract

TGF-β1 is an important growth factor that may influence the odontoblast differentiation and matrix deposition in the reactionary/reparative dentinogenesis to dental caries or other tooth injuries. TGF-β1 exerts its effects through various signaling pathways, such as Smads and MAPKs. Cyclooxygenase-2 (COX-2) is a membrane-associated enzyme that produces prostaglandin E2 (PGE2) at sites of pulpal injury and inflammation, which leads to tissue swelling, redness and pain. The purposes of this study were to investigate the differential signal transduction pathways of TGF-β1 that mediate COX-2 stimulation and PGE2 production in dental pulp cells.

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Journal

Journal ID (iso-abbrev): J. Formos. Med. Assoc.

Title: Journal of the Formosan Medical Association = Taiwan yi zhi

Publisher: Elsevier BV

ISSN: 0929-6646

ISSN (Print): 0929-6646

Publication date (Electronic): Oct 2017

Volume: 116

Issue: 10

Affiliations

[1 ] School of Dentistry, College of Medicine, National Taiwan University Medical College and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.

[2 ] School of Dentistry, Taipei Medical University, Taipei, Taiwan.

[3 ] Biomedical Science Team, Chang Gung University of Science and Technology, Kwei-Shan, Taoyuan City, Taiwan; Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan. Electronic address: mcchang@mail.cgust.edu.tw.

[4 ] School of Dentistry, College of Medicine, National Taiwan University Medical College and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: leejj@ntuh.gov.tw.

[5 ] Department of Dentistry, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

[6 ] Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan.

[7 ] Department of Dentistry, Mackey Memorial Hospital, Taipei, Taiwan.

[8 ] School of Dentistry, College of Medicine, National Taiwan University Medical College and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: jhjeng@ntu.edu.tw.

Article

Publisher Item ID: S0929-6646(17)30383-2

DOI: 10.1016/j.jfma.2017.07.008

PubMed ID: 28779848

SO-VID: 8264ba58-f147-4ede-aa5a-5e11191415f8

History

Keywords: TGF-β1,Dental pulp,Inflammation,Prostaglandin,Repair/regeneration,Signal transduction

Data availability:

Keywords: TGF-β1, Dental pulp, Inflammation, Prostaglandin, Repair/regeneration, Signal transduction

TGF-β1 stimulates cyclooxygenase-2 expression and PGE2 production of human dental pulp cells: Role of ALK5/Smad2 and MEK/ERK signal transduction pathways.

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