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      Impaired Copulatory Behaviour of Male Rats with Hyperprolactinaemia Induced by Domperidone or Pituitary Grafts

      ,

      Neuroendocrinology

      S. Karger AG

      Male sexual behaviour, Hyperprolactinaemia, Domperidone, Pituitary grafts

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          Abstract

          Sexually experienced male CFHB rats, castrated and implanted with testosterone, were chronically treated with domperidone (ca. 5 mg/kg/day). Twice-weekly tests of sexual behaviour showed a significant elevation of both mount latency and ejaculation latency, and suppression of mounting rate after 2–3 weeks of treatment. The number of mounts and intromissions before ejaculation was increased on some tests by domperidone. Experienced male WAG rats, also castrated and testosterone implanted, received three pituitary grafts under the kidney capsule. An increase in ejaculation latency was seen during the first week and then again several weeks after grafting, though implantation of non-endocrine tissue (muscle) into the controls may also have affected behaviour. Both treatments elevated serum prolactin levels, domperidone much more substantially than pituitary grafts. Serum testosterone levels were sustained within the normal intact range by the implants. The weights of the seminal vesicles, ventral prostate and adrenal glands were not significantly altered by either treatment. These experiments show that hyperprolactinaemia induced by two independent methods can retard sexual behaviour in male rats.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1982
          1982
          26 March 2008
          : 35
          : 3
          : 186-193
          Affiliations
          Department of Anatomy, University of Cambridge, Cambridge, UK
          Article
          123379 Neuroendocrinology 1982;35:186–193
          10.1159/000123379
          7133322
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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