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      Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor.

      1 , , , ,
      Investigative radiology

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          Abstract

          The authors developed a new method for delivering contrast agents to tumors and tumor cells. Gadolinium complexes of folate-conjugated dendrimer-chelates increased the longitudinal relaxation rate of tumor cells expressing the high-affinity folate receptor, hFR. The coupling of folate to polymeric chelates, composed of a dendrimer backbone, targets these chelates to endogenous folate binding proteins. These proteins exist in both the serum of patients with cancer and on the cell surface of many human cancers of epithelial origin.

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          Author and article information

          Journal
          Invest Radiol
          Investigative radiology
          0020-9996
          0020-9996
          Dec 1997
          : 32
          : 12
          Affiliations
          [1 ] Biomedical Magnetic Resonance Laboratory, College of Medicine, University of Illinois, Urbana-Champaign, USA.
          Article
          10.1097/00004424-199712000-00005
          9406015
          827a1985-3449-411c-b06e-7587568a6650
          History

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