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Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle.
Marco Ciccarelli
1
,
2 ,
Viviana Vastolo
1
,
2 ,
Luigi Albano
1
,
2 ,
Manuela Lecce
1
,
2 ,
Serena Cabaro
1
,
2 ,
Antonietta Liotti
1
,
2 ,
Michele Longo
1
,
2 ,
Francesco Oriente
1
,
2 ,
Gian Luigi Russo
3 ,
Paolo Emidio Macchia
4 ,
Pietro Formisano
1
,
2 ,
Francesco Beguinot
1
,
2 ,
Paola Ungaro
5
,
6
Jan 2016
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Abstract
Chronic hyperglycaemia worsens insulin resistance in individuals with type 2 diabetes. Whether this effect is contributed by epigenetic dysregulation and which genes are involved remain unclear. Prep1 (also known as Pknox1) is a gene exerting major effects on the sensitivity of the glucose transport machinery to insulin. Here, we show that dysregulation of Prep1 expression by high glucose levels is associated with histone modifications at its 5' regulatory region.