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      Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide.

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          Abstract

          Recent metabolomics and animal model studies show trimethylamine-N-oxide (TMAO), an intestinal microbiota-dependent metabolite formed from dietary trimethylamine-containing nutrients such as phosphatidylcholine (PC), choline, and carnitine, is linked to coronary artery disease pathogenesis. Our aim was to examine the prognostic value of systemic choline and betaine levels in stable cardiac patients.

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          Author and article information

          Journal
          Eur Heart J
          European heart journal
          Oxford University Press (OUP)
          1522-9645
          0195-668X
          Apr 2014
          : 35
          : 14
          Affiliations
          [1 ] Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
          Article
          ehu002
          10.1093/eurheartj/ehu002
          3977137
          24497336
          828fefd8-54d3-4c2a-a8ab-2be93f37d3b4
          History

          Cardiovascular disease,Choline,Gut microbiota,Myocardial infarction,Nutrition

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