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      Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress.

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          Abstract

          This study aimed to investigate the protective effects of Danshen (Salvia miltiorrhiza) water extract (DSE) and its major phenolic acid components against CYP2E1-mediated paracetamol (APAP)-induced hepatic toxicity.

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          Author and article information

          Journal
          J. Pharm. Pharmacol.
          The Journal of pharmacy and pharmacology
          Wiley-Blackwell
          2042-7158
          0022-3573
          Jul 2015
          : 67
          : 7
          Affiliations
          [1 ] School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
          [2 ] School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
          [3 ] Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
          Article
          10.1111/jphp.12381
          25645193
          829714bc-c813-40f6-9eff-80868591c5e2
          History

          Salvia miltiorrhiza,CYP2E1,oxidative stress,paracetamol,primary rat hepatocytes

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