Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.

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Abstract

The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor) in combination with febuxostat (xanthine oxidase inhibitor) in patients with gout.

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Journal ID (iso-abbrev): Rheumatology (Oxford)

Title: Rheumatology (Oxford, England)

ISSN (Electronic): 1462-0332

ISSN (Print): 1462-0324

Publication date (Electronic): Dec 2014

Volume: 53

Issue: 12

Affiliations

[1 ] Metroplex Clinical Research Center, Dallas, TX, Ardea Biosciences and Translational Sciences Department, Clinical Department, Regulatory Department and Biology Department, Ardea Biosciences, San Diego, CA, USA. rfleischmann@mcrcdallas.com.

[2 ] Metroplex Clinical Research Center, Dallas, TX, Ardea Biosciences and Translational Sciences Department, Clinical Department, Regulatory Department and Biology Department, Ardea Biosciences, San Diego, CA, USA.

Article

Publisher Item ID: ket487

DOI: 10.1093/rheumatology/ket487

PubMed ID: 24509406

SO-VID: 82a18170-536b-47f0-b715-7508e6900b02

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Keywords: drug–drug interaction,febuxostat,gout,lesinurad,pharmacodynamic,pharmacokinetic,selective uric acid reabsorption inhibitor,xanthine oxidase inhibitor

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Keywords: drug–drug interaction, febuxostat, gout, lesinurad, pharmacodynamic, pharmacokinetic, selective uric acid reabsorption inhibitor, xanthine oxidase inhibitor

Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.

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