0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Staphylococcus aureus Resistentes a meticilina en animales de granja en Suramérica: una revisión sistemática Translated title: Methicillin-resistant Staphylococcus aureus in farm animals in South America: a systematic review Translated title: Staphylococcus aureus resistentes à meticilina em animais de fazenda em américa do Sul: uma revisão sistemática

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resumen La interacción entre los seres humanos y los animales de granja aumenta el riesgo de contagio con patógenos causantes de enfermedades zoonóticas. Entre estos patógenos destacan las cepas de Staphylococcus aureus resistentes a meticilina (SARM). Inicialmente identificadas como causantes de enfermedades intrahospitalarias, hoy se sabe que estas cepas también se transmiten en la comunidad infectando, además, a distintos animales. Lamentablemente, existen pocos estudios en torno a este importante tema de salud pública, particularmente en América del Sur. Este trabajo sistematiza la información disponible en relación con la ocurrencia de cepas SARM en animales de granja en dicha región. Para ello, se realizó una revisión de la información disponible en bases de datos como Scopus, Medline y Scielo, de acuerdo a las recomendaciones de la declaración PRISMA. Se incluyeron artículos publicados en los últimos diez años, que hagan referencia la ocurrencia de cepas SARM en animales de granja, en países de América del Sur. De un total de 65 artículos, se seleccionaron 19. De estos,13 se realizaron en Brasil, dos en Ecuador, uno en Chile, Uruguay y Perú, respectivamente; un último trabajo incluye datos de varios países. La mayoría de los estudios caracterizaron cepas SARM aisladas a partir de ganado vacuno, siendo los cerdos los animales que ocupan la segunda posición de interés. En muchos de estos estudios se emplearon técnicas de biología molecular. Aunque en general no fueron reportados datos importantes como la prevalencia o el período de muestreo, destaca una elevada ocurrencia de cepas SARM multirresistentes en estos animales.

          Translated abstract

          Abstract The interaction between humans and farm animals increases the risk of infection with a zoonotic pathogen. Among these pathogens, methicillin-resistant Staphylococcus aureus (MRSA) strains stand out. Initially identified as the cause of hospital-acquired diseases, it is acknowledged nowadays that these strains are also transmitted in the community, being able to infect different animals. Unfortunately, few studies on this important public health issue have been published, particularly concerning the South American region. Here we systematize the available information on the occurrence of MRSA strains in farm animals in South-American countries. For this, a systematic review of the information available in the bibliographic databases Scopus, Medline and Scielo was carried out, following PRISMA standards. Articles published in the last ten years referring the occurrence of MRSA strains in farm animals in South America were included. From a total of 65 articles, 19 were selected. Of these, 13 were conducted in Brazil, two in Ecuador, one in Chile, Uruguay and Peru, respectively; a last study includes data from several countries. Most of the studies characterized MRSA strains isolated from cattle, with pigs being the second most important animal of interest. Molecular biology techniques were used in many of these studies. Although in many cases important data such as prevalence or sampling period were not reported, a high occurrence of multidrug-resistant MRSA strains in these animals stands out.

          Translated abstract

          Resumo A interação entre humanos e animais de fazenda aumenta o risco de infecção com um agente zoonótico patogénico. Entre estes agentes patogénicos destacam-se as cepas de Staphylococcus aureus resistente à meticilina (MRSA). Inicialmente identificadas como a causa de doenças adquiridas em hospitais, reconhece-se hoje em dia que estas cepas também são transmitidas na comunidade, podendo infectar diferentes animais. Infelizmente, poucos estudos sobre esta importante questão de saúde pública foram publicados, particularmente no que diz respeito à região da América do Sul. Aqui sistematizamos a informação disponível sobre a ocorrência de MRSA em animais de fazenda em países sul-americanos. Para tal, foi realizada uma revisão sistemática da informação disponível nas bases de dados bibliográficas Scopus, Medline e Scielo, seguindo as normas PRISMA. Foram incluídos artigos publicados nos últimos dez anos, referindo a ocorrência de cepas MRSA em animais de fazenda na América do Sul. De um total de 65 artigos, foram seleccionados 19. Destes, 13 foram realizados no Brasil, dois no Equador, um no Chile, Uruguai e Peru, respectivamente; um último estudo inclui dados de vários países. A maioria dos estudos caracterizou cepas de MRSA isoladas de bovinos, sendo os suínos o segundo animal de maior interesse. Em muitos de estos artigos foram utilizadas técnicas de biologia molecular. Embora em muitos casos não tenham sido comunicados dados importantes, tais como prevalência ou período de amostragem, destaca-se a elevada ocorrência de cepas multirresistentes de MRSA nestes animais.

          Related collections

          Most cited references40

          • Record: found
          • Abstract: found
          • Article: not found

          Coronavirus Disease 2019–COVID-19

          In recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory syndrome CoV-2 (SARS-CoV-2). Although coronavirus disease 2019 (COVID-19) is suspected to originate from an animal host (zoonotic origin) followed by human-to-human transmission, the possibility of other routes should not be ruled out.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis

            Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient populations in hospitals around the world. Intensive care unit (ICU) patients are particularly susceptible to nosocomial infections due to indwelling devices such as intravascular catheters, drains, and intratracheal tubes for mechanical ventilation. The increased vulnerability of infected ICU patients demonstrates the importance of effective outbreak management protocols to be in place. Understanding the transmission of pathogens via genotyping methods is an important tool for outbreak management. Recently, whole-genome sequencing (WGS) of pathogens has become more accessible and affordable as a tool for genotyping. Analysis of the entire pathogen genome via WGS could provide unprecedented resolution in discriminating even highly related lineages of bacteria and revolutionize outbreak analysis in hospitals. Nevertheless, clinicians have long been hesitant to implement WGS in outbreak analyses due to the expensive and cumbersome nature of early sequencing platforms. Recent improvements in sequencing technologies and analysis tools have rapidly increased the output and analysis speed as well as reduced the overall costs of WGS. In this review, we assess the feasibility of WGS technologies and bioinformatics analysis tools for nosocomial outbreak analyses and provide a comparison to conventional outbreak analysis workflows. Moreover, we review advantages and limitations of sequencing technologies and analysis tools and present a real-world example of the implementation of WGS for antimicrobial resistance analysis. We aimed to provide health care professionals with a guide to WGS outbreak analysis that highlights its benefits for hospitals and assists in the transition from conventional to WGS-based outbreak analysis.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Adaptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy.

              For the past 2 decades, vancomycin has served as the cornerstone of therapy against serious methicillin-resistant Staphylococcus aureus infections. This role is increasingly challenged by questions of efficacy, including reduced efficacy against infections caused by glycopeptide-intermediate S. aureus strains. In an evaluation of clinical glycopeptide-intermediate S. aureus isolates and serial, clinical methicillin-resistant S. aureus isolates obtained from patients receiving vancomycin for the treatment of bacteremia, we found that loss of function of the accessory gene regulator operon may confer a survival advantage to S. aureus under vancomycin selection pressure, particularly in strains with the accessory gene regulator group II genotype. Other advantages in a nosocomial setting may include enhancement of biofilm formation and promotion of physiologic changes supporting colonization. We conclude that loss of accessory gene regulator function in methicillin-resistant S. aureus might, in part, explain the decreased efficacy of vancomycin in the therapy of methicillin-resistant S. aureus bacteremia, thus highlighting the need to reevaluate the criteria of susceptibility to vancomycin.
                Bookmark

                Author and article information

                Journal
                vrs
                Vive Revista de Salud
                Vive Rev. Salud
                CET-BOLIVIA (La Paz, , Bolivia )
                2664-3243
                August 2021
                : 4
                : 11
                : 246-265
                Affiliations
                [2] orgname
                [1] orgname
                Article
                S2664-32432021000200246 S2664-3243(21)00401100246
                10.33996/revistavive.v4i11.99
                82aaffa9-d744-48cd-b1db-43cc52814dd3

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 22 March 2021
                : 10 April 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 40, Pages: 20
                Product

                SciELO Bolivia

                Categories
                INVESTIGACIÓN

                resistência microbiana a medicamentos,revisão sistemática,fazendaa,animais,SARM,Staphylococcus aureus resistente à meticilina,Resistencia a antibióticos,revisión sistemática,granjas,animales,Staphylococcus aureus resistente a meticilina,antibiotic resistance,systematic review,farms,animals,MRSA,Methicillin-resistant Staphylococcus aureus

                Comments

                Comment on this article