Blog
About

16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      NMD: a multifaceted response to premature translational termination.

      Nature reviews. Molecular cell biology

      Codon, Nonsense, metabolism, Transcription Factors, Trans-Activators, genetics, Ribosomes, Ribonucleoproteins, RNA-Binding Proteins, RNA, Messenger, RNA Stability, Protein Biosynthesis, Peptide Termination Factors, Peptide Chain Termination, Translational, Nonsense Mediated mRNA Decay, Humans

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although most mRNA molecules derived from protein-coding genes are destined to be translated into functional polypeptides, some are eliminated by cellular quality control pathways that collectively perform the task of mRNA surveillance. In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that destabilize a targeted mRNA. The same factors also seem to have key roles in repressing the translation of the mRNA, dissociating its terminating ribosome and messenger ribonucleoproteins (mRNPs), promoting the degradation of its truncated polypeptide product and possibly even feeding back to the site of transcription to interfere with splicing of the primary transcript.

          Related collections

          Author and article information

          Journal
          23072888
          10.1038/nrm3454
          3970730

          Comments

          Comment on this article