The transcription cofactor FgSwi6 plays a role in growth and development, carbendazim sensitivity, cellulose utilization, lithium tolerance, deoxynivalenol production and virulence in the filamentous fungus Fusarium graminearum
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Abstract
Fusarium head blight (FHB) is a worldwide devastating disease of wheat, barley and
other small grain cereals and caused primarily by Fusarium graminearum. Carbendazim
(MBC) is one of the fungicides widely used to control FHB in China. In the present
study, we have identified the F. graminearum locus FGSG_04220 as the sequence homolog
for Saccharomyces cerevisiae ScSWI6, named FgSWI6 hereafter. Deletion of FgSWI6 causes
mycelium of F. graminearum become sensitive to MBC in liquid medium. In addition,
deletion of FgSWI6 reduces mycelial growth as well as production and development of
conidia. F. graminearum cells lacking FgSWI6 show reduced production efficiency and
sizes of perithecia as well as a defect in the production of ascus and ascospore.
FgSWI6 is required for the cellulose utilization, lithium tolerance and deoxynivalenol
(DON) production of this pathogen. Furthermore, deletion of FgSWI6 significantly attenuates
the virulence of F. graminearum on wheat. Therefore, FgSwi6p plays an important role
in growth and development of the economically important fungal pathogen F. graminearum
as well as its resistance to MBC.