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      Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk.

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          Abstract

          The manganese superoxide dismutase (MnSOD) gene encodes an antioxidant enzyme (SOD2) that may protect cells from oxidative damage. The MnSOD allele with Val as amino acid 16 encodes a protein that has 30-40% lower activity compared with the MnSOD Ala variant, hence possibly increasing susceptibility to oxidative stress. On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer.

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          Author and article information

          Journal
          Carcinogenesis
          Carcinogenesis
          Oxford University Press (OUP)
          1460-2180
          0143-3334
          Dec 2008
          : 29
          : 12
          Affiliations
          [1 ] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
          Article
          bgn212
          10.1093/carcin/bgn212
          2722865
          18784358
          82c7bfb0-977b-4f89-8b0f-bc467acbf062
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