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      Serum vitamin D expression in advanced schistosomiasis patients with hepatic fibrosis and its association with disease progression

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          Abstract

          Objective To compare the expression of serum vitamin D in advanced schistosomiasis patients with grade I and II hepatic fibrosis, and to preliminarily examine its associations with the internal diameter of the main portal vein and progression of hepatic fibrosis.

          Methods The medical records of 126 advanced schistosomiasis patients with grade I and II hepatic fibrosis referred to Jiaxing First Hospital from March 2012 to September 2015 were retrospectively analyzed. The internal diameter of the main portal vein and serum 25-hydroxyvitamin D3 [25(OH)D3] level were measured. The progression of hepatic fibrosis was followed up, and the serum vitamin D level was compared between patient with disease progression and stable disease.

          Results The 126 advanced schistosomiasis patients included 72 men and 54 women, and had ages of 62 to 80 years. There were 58 cases with grade I hepatic fibrosis and 68 cases with grade II hepatic fibrosis. There were significant differences between patients with grade I and II hepatic fibrosis in terms of hemoglobin, white blood cell count, prothrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen or 25(OH)D3 level (all P > 0.05), and significant differences were seen in alanine aminotransferase, aspartate aminotransferase, blood calcium, blood phosphorus levels and the internal diameter of the main portal vein (all P values < 0.05). In addition, a lower serum 25(OH)D3 level was detected in patients with broadened internal diameter of the main portal vein than in those with normal internal diameter of the main portal vein [(19.08 ± 1.36) nmol/L vs. (25.61 ± 6.69) nmol/L, P < 0.05]. Following 3-year follow-up, there were 73 cases with progression of hepatic fibrosis, and a significantly lower serum vitamin D level was found in patients with disease progression than in those with stable disease [(20.00 ± 0.81) nmol/L vs. (25.47 ± 5.91) nmol/L, P < 0.05].

          Conclusions Vitamin D deficiency is common in advanced schistosomiasis patients with hepatic fibrosis, and it may be associated with the internal diameter of the main portal vein and the progression of hepatic fibrosis disease.

          Abstract

          [摘要] 目的 比较晚期血吸虫病肝纤维化I、II级患者血清维生素D表达水平, 初步探索其与患者门静脉主干内径宽度及肝纤维化进展的关系。 方法 回顾性分析2012年3月至2015年9月就诊于嘉兴市第一医院血吸虫病科的126例晚期血吸虫病肝纤维化I、II级患者临床资料, 比较两组患者门静脉主干内径宽度、25羟维生素D3[25 (OH) D3]等指标; 随访观察上述患者肝纤维化进展情况, 比较病情进展者和病情稳定者维生素D表达水平。 结果 126例晚期血吸虫病患者中, 男性72例, 女性54例; 年龄62~80岁; 肝纤维化I级58例, II级68例。肝纤维化I级和II级患者血红蛋白、白细胞计数、凝血酶原时间、国际标准化比值、活化部分凝血活酶时间、纤维蛋白原含量、25(OH)D3水平差异均无统计学意义 ( P均> 0.05), 丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血钙、血磷、门静脉主干内径宽度值差异均有统计学意义 ( P 均<0.05) ; 门静脉主干内径增宽者血清中25(OH)D3表达水平低于正常组 ([ 19.08 ± 1.36) nmol/L vs. (25.61 ± 6.69) nmol/L], 差异有统计学意义 ( P < 0.05) ; 随访3年, 发现73例患者肝纤维化病情进展, 病情进展患者血清中维生素D表达水平低于病情稳定组 ([ 20.00 ± 0.81) nmol/L vs (. 25.47 ± 5.91) nmol/L ], 差异有统计学意义 ( P < 0.05) 。 结论 维生素D缺乏在晚期血吸虫病肝纤维化患者中较常见, 其可能与患者门静脉主干内径及病情进展有关。

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          Author and article information

          Journal
          CJSC
          Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
          Chinese Journal of Schistosomiasis Control (Wuxi, China )
          1005-6661
          13 November 2019
          : 32
          : 3
          : 304-307
          Affiliations
          [1] 1Zhengzhou University People’s Hospital, Henan Province, Zhengzhou 450003, China
          [2] 2Department of Schistosomiasis, The First Hospital of Jiaxing City, Zhejiang Province, China
          Author notes
          *Corresponding author: YM Wu, E-mail: jxyywxb@ 123456163.com
          Article
          j.32.1374.2019122
          10.16250/j.32.1374.2019122
          32468796
          82d1d3da-41b8-4f93-80a1-8b42d3cc4104
          © 2020 Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Categories
          Journal Article

          Medicine,Immunology,Parasitology,Internal medicine,Public health,Infectious disease & Microbiology
          Advanced schistosomiasis,Internal diameter of the main portal vein,Hepatic fibrosis,Disease progression,25-hydroxyvitamin D3

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