Effects of Stimulation of the Preoptic Area on Hypothalamic Paraventricular Nucleus Unit Activity and Corticosterone Secretion in Freely Moving Rats

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Abstract

Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of the POA evoked increases in the rate of electrical discharge in 58% of the units tested. Increases were recorded during each period of stimulation and were subsequently followed by a significant decrease in the rate of firing. In a substantial proportion of these neurones, bursting patterns of electrical discharge were observed before, during, and following stimulation of POA. When simultaneous removal of blood samples from these animals was performed, a significant increase in plasma corticosterone concentration, immediately following POA stimulation, was observed. The data obtained have provided a possible neurophysiological correlate of hypothalamic electrical activity that may be directly related to the neural control of adrenocortical secretion.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1986

Publication date (Print): 1986

Publication date (Electronic): 01 April 2008

Volume: 42

Issue: 2

Pages: 167-173

Affiliations

Laboratory of Neurophysiology, Department of Neurology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel

Article

Publisher ID: 124269 Other ID: Neuroendocrinology 1986;42:167–173

DOI: 10.1159/000124269

PubMed ID: 3951670

SO-VID: 82d8d750-3c5c-4246-b94d-55f32a480f75

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 18 December 1984

Date accepted : 27 March 1985

Page count

Pages: 7

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