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      Effects of Stimulation of the Preoptic Area on Hypothalamic Paraventricular Nucleus Unit Activity and Corticosterone Secretion in Freely Moving Rats

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          Abstract

          Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of the POA evoked increases in the rate of electrical discharge in 58% of the units tested. Increases were recorded during each period of stimulation and were subsequently followed by a significant decrease in the rate of firing. In a substantial proportion of these neurones, bursting patterns of electrical discharge were observed before, during, and following stimulation of POA. When simultaneous removal of blood samples from these animals was performed, a significant increase in plasma corticosterone concentration, immediately following POA stimulation, was observed. The data obtained have provided a possible neurophysiological correlate of hypothalamic electrical activity that may be directly related to the neural control of adrenocortical secretion.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1986
          1986
          01 April 2008
          : 42
          : 2
          : 167-173
          Affiliations
          Laboratory of Neurophysiology, Department of Neurology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel
          Article
          124269 Neuroendocrinology 1986;42:167–173
          10.1159/000124269
          3951670
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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