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Molecular epidemiology and KSHV K1 subtypes in a Cuban AIDS-Kaposi's sarcoma population.

AIDS (London, England)

virology, Acquired Immunodeficiency Syndrome, complications, Amino Acid Sequence, Cuba, epidemiology, Female, Genes, Viral, Herpesvirus 8, Human, classification, genetics, Humans, Male, Molecular Sequence Data, Phylogeny, Sarcoma, Kaposi

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      Kaposi's sarcoma-associated herpesvirus (KSHV) is detected consistently in Kaposi's sarcoma (KS). Because of its dramatic sequence variation, the K1 gene has been used to classify KSHV. We found a diverse array of KSHV subtypes A1, A2, A3, A5, B1, B2, and C3 in 23 Cuban KS samples containing several novel sporadic insertions/deletions in subtypes A and C. The molecular epidemiology of the KSHV subtypes seems to reflect the unique mixed ethnic background of the Cuban population.

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