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      Borrelia burgdorferi glycosaminoglycan-binding proteins: a potential target for new therapeutics against Lyme disease

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          Abstract

          The spirochete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. The spirochetes can be transmitted to humans via ticks, and then spread to different tissues, leading to arthritis, carditis and neuroborreliosis. Although antibiotics have commonly been used to treat infected individuals, some treated patients do not respond to antibiotics and experience persistent, long-term arthritis. Thus, there is a need to investigate alternative therapeutics against Lyme disease. The spirochete bacterium colonization is partly attributed to the binding of the bacterial outer-surface proteins to the glycosaminoglycan (GAG) chains of host proteoglycans. Blocking the binding of these proteins to GAGs is a potential strategy to prevent infection. In this review, we have summarized the recent reports of B. burgdorferi sensu lato GAG-binding proteins and discussed the potential use of synthetic and semi-synthetic compounds, including GAG analogues, to block pathogen interaction with GAGs. Such information should motivate the discovery and development of novel GAG analogues as new therapeutics for Lyme disease. New therapeutic approaches should eventually reduce the burden of Lyme disease and improve human health.

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          Author and article information

          Journal
          Microbiology (Reading)
          Microbiology (Reading)
          Micro
          Microbiology
          Microbiology Society
          1350-0872
          1465-2080
          December 2017
          8 November 2017
          8 November 2017
          : 163
          : 12
          : 1759-1766
          Affiliations
          [ 1] Division of Infectious Disease, Wadsworth Center, New York State Department of Health , Albany, NY, USA
          [ 2] Department of Biomedical Science, State University of New York at Albany , Albany, NY, USA
          [ 3] Division of Environmental Health Science, Wadsworth Center, New York State Department of Health , Albany, NY, USA
          [ 4] Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, NY, USA
          [ 5] Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, NY, USA
          [ 6] Departments of Biology and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, NY, USA
          Author notes
          *Correspondence: Yi-Pin Lin, Yi-Pin.Lin@ 123456health.ny.gov
          Robert J. Linhardt, linhar@ 123456rpi.edu
          Article
          PMC5845733 PMC5845733 5845733 000571
          10.1099/mic.0.000571
          5845733
          29116038
          © 2017 The Authors
          Funding
          Funded by: New York State Department of Health - Wadsworth Center
          Award ID: Start-Up Grant
          Funded by: National Institutes of Health
          Award ID: HL094463
          Funded by: National Institutes of Health
          Award ID: HL136271
          Funded by: National Institutes of Health
          Award ID: HL125371
          Funded by: National Institutes of Health
          Award ID: HL125371
          Categories
          Review
          Host-Microbe Interaction
          Custom metadata
          12

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