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      Efficacy of psychedelic treatments on depressive symptoms: A meta-analysis

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          Abstract

          Background:

          Psychedelic drugs have shown an efficacy in some psychiatric disorders and have an original mechanism of action with a 5-HT 2A agonism.

          Aim:

          The aim of this meta-analysis was to assess by a quantitative analysis the putative efficacy of psychedelic drugs on depressive symptoms and to investigate the kinetic of this efficacy.

          Methods:

          We searched the MEDLINE and PsycINFO databases through April 2019, without limits on year of publication. Means and standard deviations were extracted to calculate standardized mean differences (SMD). Scores of depressive symptoms were compared with baseline scores at days 7, 14, and 21; weeks 4–5 and 6–8; and months 3 and 6.

          Results:

          Eight studies were included in this meta-analysis. A significant decrease of depressive symptoms was found from day 1 ( n = 5 studies; SMD = ‒1.4, 95% confidence interval (CI): ‒2.33 to ‒0.48, p = 0.003) to 6 months ( n = 4 studies; SMD = ‒1.07, 95% CI: ‒1.44 to ‒0.7, p < 0.001) after psychedelic sessions. No serious adverse effect was reported in all included studies. A transient increase of the heart rate, blood systolic, and diastolic pressure were found after psychedelics compared with placebo.

          Conclusion:

          This meta-analysis shows that psychedelic treatments were safe and could contribute to a rapid improvement of depressive symptoms.

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          Most cited references1

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          Cochrane Handbook for Systematic Reviews of Interventions 4.2.6

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            Author and article information

            Contributors
            Journal
            Journal of Psychopharmacology
            J Psychopharmacol
            SAGE Publications
            0269-8811
            1461-7285
            October 2020
            May 25 2020
            October 2020
            : 34
            : 10
            : 1079-1085
            Affiliations
            [1 ]Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France
            [2 ]Faculte de Medecine, Paris Sud University, Le Kremlin-Bicetre, Île-de-France, France
            [3 ]Institut National de la Santé et de la Recherche Médicale, Paris, France
            [4 ]Unité Psychiatrie-Comorbidités-Addictions-Unité de Recherche PSYCOMADD 4872; Université Paris-Sud-APHP, Université Paris Saclay, Villejuif France
            [5 ]Institut National de la Santé et de la Recherche Médicale, Research unit, NeuroImaging and Psychiatry, Paris Sud University-Paris Saclay University, Paris Descartes University, Digiteo Labs, Gif-sur- Yvette, France
            Article
            10.1177/0269881120919957
            32448048
            830cf5ce-3089-4d12-907e-af7d71152b39
            © 2020

            http://journals.sagepub.com/page/policies/text-and-data-mining-license

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