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      Action of Angiotensin in Normal, Adrenalectomized, and Renal Hypertensive Trained Dogs

      Nephron

      S. Karger AG

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          Abstract

          The relationship between filtration rate (GFR) and electrolyte excretion was investigated during infusions of low doses of angiotensin II (0.02 to 2.0 µg/sq m/min) by means of repeated clearance experiments in trained normal, adrenalectomized, and chronic experimental renal hypertensive dogs. A limited number of experiments were conducted also in dogs anesthetized with pentobarbital. Parameters of BP, C<sub>In</sub>, C<sub>pAH</sub>, U<sub>Na</sub>, and U<sub>k</sub> were determined simultaneously under conditions of a moderate water diuresis. Alterations in GFR were produced by varying the dose of angiotensin, thereby allowing a study of electrolyte excretion under conditions of decreased, relatively unchanged, and increased filtered loads. The data was grouped for statistical analysis on the basis of whether the change in GFR from control was more than –5%, within ± 5%, or above +5%. Sodium excretion (U<sub>Na</sub>V) was found to parallel the change in GFR in the three types of dogs. Potassium excretion (U<sub>k</sub>V) showed also a relationship with GFR in the normal and hypertensive dogs but fell significantly below control in the adrenalectomized dogs when GFR remained at control levels (within ± 5%). Significant alterations in tubular sodium transport were not apparent at the low doses of angiotensin used in this study. A dampened renal vasomotor response was observed in the hypertensive dogs which was associated with a greater tendency of GFR to increase above control. It is concluded that under the conditions of this study low doses of angiotensin can produce a decrease, no change, or an increase in the excretion of sodium as a result of the drug’s action on the renal vascular bed to alter GFR.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1968
          1968
          26 November 2008
          : 5
          : 4
          : 265-281
          Affiliations
          Department of Physiology, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, N.C.
          Article
          179636 Nephron 1968;5:265–281
          10.1159/000179636
          4299411
          © 1968 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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