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      Immunochemical Localization of Transforming Growth Factor-α-Related Protein in the Rat Kidney

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          Abstract

          Transforming growth factor-α (TGF-α) is a 50-amino acid polypeptide synthesized as part of a larger precursor of 159 amino acids. Its expression has been reported in normal and neoplastic kidney. In this report, we characterized a renal TGF-α-immunoreactive protein, which we named TGF-α-related protein (TGF-α-RP). It was found to be present in the final part of the collecting tubules of the normal rat kidney. Western blotting analysis of kidney samples revealed a protein of 38 kD and pI = 5.5. In nonreducing conditions immunoreaction for this protein decreased and a TGF-α-immunoreactive protein of 150 kD was observed. The expression of TGF-α-RP seems to be highly conserved in the kidney of mammals and chickens. Therefore, TGF-α-RP may have an important role in the normal development and function of the kidney.

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          Structure and function of epidermal growth factor-like regions in proteins.

          E Appella, Monica F. Blasi, Alice I Weber (1988)
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            Author and article information

            Journal
            Journal ID (publisher-id): NEF
            Journal ID (nlm-ta): Nephron
            Journal ID (doi): 10.1159/issn.1660-8151
            Title: Nephron
            Publisher: S. Karger AG
            ISSN (Print): 1660-8151
            ISSN (Electronic): 2235-3186
            Publication date Subscription-year: 1999
            Publication date (Print): March 1999
            Publication date (Electronic): 26 February 1999
            Volume: 81
            Issue: 3
            Pages: 324-328
            Affiliations
            Departament de Biologia Cel.lular i Anatomia Patològica, Unitat de Proliferació i Diferenciació Cel.lular, Universitat de Barcelona, L’Hospitalet (Barcelona), Spain
            Article
            Publisher ID: 45300 Other ID: Nephron 1999;81:324–328
            DOI: 10.1159/000045300
            PubMed ID: 10050088
            SO-VID: 831024ed-9641-400a-b3cc-06bd54b2bb51
            Copyright © © 1999 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 3, References: 26, Pages: 5
            Categories
            Subject: Original Paper

            ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
            Keywords: Transforming growth factor-α,Kidney,Rat,Immunohistochemistry,Western blotting
            Data availability:
            ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
            Keywords: Transforming growth factor-α, Kidney, Rat, Immunohistochemistry, Western blotting

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