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      Immunochemical Localization of Transforming Growth Factor-α-Related Protein in the Rat Kidney

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          Abstract

          Transforming growth factor-α (TGF-α) is a 50-amino acid polypeptide synthesized as part of a larger precursor of 159 amino acids. Its expression has been reported in normal and neoplastic kidney. In this report, we characterized a renal TGF-α-immunoreactive protein, which we named TGF-α-related protein (TGF-α-RP). It was found to be present in the final part of the collecting tubules of the normal rat kidney. Western blotting analysis of kidney samples revealed a protein of 38 kD and pI = 5.5. In nonreducing conditions immunoreaction for this protein decreased and a TGF-α-immunoreactive protein of 150 kD was observed. The expression of TGF-α-RP seems to be highly conserved in the kidney of mammals and chickens. Therefore, TGF-α-RP may have an important role in the normal development and function of the kidney.

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          Structure and function of epidermal growth factor-like regions in proteins.

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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            1999
            March 1999
            26 February 1999
            : 81
            : 3
            : 324-328
            Affiliations
            Departament de Biologia Cel.lular i Anatomia Patològica, Unitat de Proliferació i Diferenciació Cel.lular, Universitat de Barcelona, L’Hospitalet (Barcelona), Spain
            Article
            45300 Nephron 1999;81:324–328
            10.1159/000045300
            10050088
            © 1999 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 3, References: 26, Pages: 5
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/45300
            Categories
            Original Paper

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