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      A Study of Human Senile Cataract: Growth and Differentiation of Lens Epithelial Cells in in vitro culture

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          Abstract

          Epithelial cells of human senile cataractous lenses from aged patients (over 60) were cultured in vitro. They began to grow from the 4th to 6th day of culture and formed typical epithelial cell sheets. The lentoid identified by immunochemical methods as a mass of lens fibers were found to develop at the terminal period of the primary culture. From the secondary passage of the culture, the growth potential of the cells decayed rapidly. It was also demonstrated clearly that the senile cataractous lenses still contained a small number of active epithelial cells exhibiting rather high growth and differentiation potentials, No signficant relationships between activities of epithelial cells and the condition of cataract have been observed so far.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-0862-9
          978-3-318-02127-1
          0030-3747
          1423-0259
          1979
          1979
          03 December 2009
          : 11
          : 5-6
          : 308-315
          Affiliations
          Institute of Molecular Biology, Faculty of Science, Nagoya University, Nagoya
          Article
          265025 Ophthalmic Res 1979;11:308–315
          10.1159/000265025
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Growth Control, Differentiation, and Ageing of the Eye Lens

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