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The potential of patients' peripheral blood mononuclear cells to differentiate into dendritic cells after hematopoietic stem cell transplantation.
Hironori Yoshino
1 ,
Naoki Watanabe ,
Kenji Takahashi ,
Kazuto Ogura ,
Tomoaki Akagi ,
Kohmei Kubo ,
Ikuo Kashiwakura
Dec 19 2011
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Abstract
Although hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological disorders, there is persistent immunosuppression in both allogeneic and autologous HSCT. Dendritic cells (DCs) play key roles in the immune system. This study investigated whether the DC progenitor cells within patients' peripheral blood after HSCT have the potential to differentiate into DCs.