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      Repeatability and Reproducibility of Foveal Avascular Zone Area Measurement on Normal Eyes by Different Optical Coherence Tomography Angiography Instruments

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          Abstract

          Purpose: To compare the foveal avascular zone (FAZ) area measurements produced by different optical coherence tomography angiography (OCTA). Methods: Healthy enrolled volunteers underwent OCTA using 2 different devices: Spectralis HRA+OCTA (Heidelberg Engineering, Heidelberg, Germany) and RS-3000 Advance (Nidek, Gamagori, Japan). Two graders measured FAZ in both superficial (SCP) and deep (DCP) retinal capillary plexuses. The SCP and DCP en face images were visualized automatically segmenting 2 separate slabs defined by the arbitrary segmentation lines created by the software of each OCT device. One grader repeated each measure twice. Results: Fifty-nine eyes were included. The mean FAZ was 0.33 ± 0.09 mm<sup>2</sup> at the SCP and 0.57 ± 0.17 mm<sup>2</sup> at the DCP measured with RS-3000 versus 0.30 ± 0.08 and 0.35 ± 0.08 mm<sup>2</sup>, respectively, measured with Spectralis. The measurements of the 2 devices were significantly different ( p < 0.0001). The intraoperator agreement was excellent at the SCP (intraclass correlation coefficient, ICC: 0.97 with Spectralis and 0.96 with RS-3000). At the DCP, it was good with Spectralis and fair with RS-3000 (ICC: 0.85 and 0.64, respectively). The interoperator agreement was excellent for Spectralis and good for RS-3000 at the SCP (ICC: 0.97 and 0.93, respectively). It was good at the DCP with both devices (ICC: 0.74 with RS-3000 and 0.81 with Spectralis). Conclusions: FAZ measurements obtained with different OCTA devices differ. These findings should be considered in follow-up studies of patients with retinal vascular diseases.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          2018
          May 2018
          08 February 2018
          : 59
          : 4
          : 206-211
          Affiliations
          [_a] aDepartment of Ophthalmology, University of Padova, Padova, Italy
          [_b] bG.B. Bietti Foundation, IRCCS, Rome, Italy
          Author notes
          *Edoardo Midena, MD, Department of Ophthalmology, University of Padova, Via Giustiniani 2, IT–35128 Padova (Italy), E-Mail edoardo.midena@unipd.it
          Article
          485463 Ophthalmic Res 2018;59:206–211
          10.1159/000485463
          29421813
          831c4261-1c45-42d8-8503-011390e1d16a
          © 2018 S. Karger AG, Basel

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          History
          : 15 August 2017
          : 20 November 2017
          Page count
          Figures: 3, Pages: 6
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Optical coherence tomography angiography,Deep retinal capillary plexus,Foveal avascular zone area,Superficial retinal capillary plexus

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