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Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to
a continuous infusion of glucose via their peritoneal cavity. We performed studies
to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption
averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate dextrose concentration
of 1.5 or 4.25 g/dl. The amount of glucose absorbed per liter of dialysate (y) varied
with the concentration of glucose in dialysate (x), (y = 11.3x - 10.9, r = 0.96).
The amount of glucose absorbed per day during a given dialysis regimen was constant.
Energy intake from dialysate glucose was 8.4 +/- 2.8 kcal/kg of body wt per day, or
12 to 34% of total energy intake. This additional energy may contribute to the anabolic
effect reported during CAPD. The ability to vary glucose absorption by altering the
dialysate glucose concentration may prove a useful tool to modify energy intake.