Blog
About

6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      [Amyloidoses in the Berlin Museum of Medical History of the Charité].

      1 , ,

      Der Pathologe

      Springer Nature

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The Berliner Medizinhistorische Museum (Berlin Museum of Medical History) of the Charité is located in its own separate building and was officially opened in 1899. It currently houses 10,000 specimens, of which 23 were labelled with the diagnosis "amyloid" or "amyloidosis". In this retrospective study we aimed to histologically verify the diagnosis, classify the amyloid deposits immunohistochemically and correlate the type of amyloid with clinico-pathological data. The specimens were obtained between 1866 and 1987 and included 17 kidneys, five spleens and one liver. The diagnosis could be confirmed histologically using Congo red staining and polarization microscopy in 22 specimens. However, the diagnosis could not be confirmed in the oldest specimen, which had been labelled by Rudolf Virchow himself. Immunohistochemically amyloid was classified as either AA amyloidosis (19 cases) or AL amyloidosis (two cases). Tuberculosis was the most common cause of AA amyloidosis. This study shows that a surgical pathological re-evaluation of historical specimens can verify the original diagnosis. This is historically fascinating and also offers a valuable addition to student teaching.

          Related collections

          Author and article information

          Affiliations
          [1 ] Institut für Pathologie, Berliner Medizinhistorisches Museum der Charité, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. christoph.roecken@charite.de
          Journal
          Pathologe
          Der Pathologe
          Springer Nature
          1432-1963
          0172-8113
          May 2009
          : 30
          : 3
          19296111 10.1007/s00292-009-1135-2

          Comments

          Comment on this article