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      Perinatal Hypothyroidism Decreases Hippocampal Mossy Fiber Zinc Density in Rats

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          The effect of perinatal hypothyroidism on hippocampal mossy fiber zinc density was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either 0.02% propylthiouracil (PTU) or vehicle from gestational day 18 until their litters were weaned on postnatal day 31. Hippocampal mossy fiber zinc density was reduced by 75% in both the dorsal and ventral hippocampal formation CA3 stratum lucidum region of 31-day-old PTU-treated rats compared to untreated controls. Perinatal hypothyroidism did not alter hippocampal tissue zinc concentration, indicating that the PTU-induced reduction in mossy fiber zinc was not a consequence of reduced hippocampal zinc concentration. At 120 days of age, 3 months after discontinuation of PTU treatment, hippocampal mossy fiber zinc density remained significantly reduced by 33-45% in PTU-treated rats compared to control. These data indicate that perinatal hypothyroidism causes a long-lasting reduction in hippocampal mossy fiber zinc density.

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          Author and article information

          S. Karger AG
          07 April 2008
          : 55
          : 1
          : 20-27
          aDepartment of Pharmacology, University of New Mexico School of Medicine, Albuquerque, N. Mex. bDepartments of Neurology and Toxicology, University of Kentucky and Veterans Administration Medical Center, Lexington, Ky., USA
          126092 Neuroendocrinology 1992;55:20–27
          © 1992 S. Karger AG, Basel

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          Pages: 8
          Original Paper


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