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      Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

      review-article
      Author(s): 1 , 2 , 3 , 2 , *
      Publication date (Electronic):
      Journal: Pharmaceutics
      Publisher: MDPI
      Keywords: niosome, drug delivery, non-ionic surfactant, carrier, stability

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          Abstract

          Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery.

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          Nonviral vectors for gene delivery.

          Meredith A. Mintzer, Eric Simanek (2009)
          Article 0 comments Cited 444 times – based on 0 reviews     Review now
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            A Decade of the Protein Corona.

            Frank Caruso, Thomas P. Davis, Wolfgang Parak … (2017)
            In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the "biocorona", a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.
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              Nano-niosomes as nanoscale drug delivery systems: an illustrated review.

              Afra Hadjizadeh, Saeid Moghassemi (2014)
              The field of nanochemistry research has shown a great progress in the developing of novel nanocarriers as potential drug delivery systems. Niosome is a class of molecular cluster formed by self-association of non-ionic surfactants in an aqueous phase. The unique structure of niosome presents an effective novel drug delivery system (NDDS) with ability of loading both hydrophilic and lipophilic drugs. Numerous research articles have been published in scientific journals, reporting valuable results of individual case studies in this context. However, surveying and discussing the recent, rapidly growing reported studies along with their theoretical principals is required for the fully understanding and exploring the great potential of this approach. To this aim, we have provided an illustrated and comprehensive study from the view of a supramolecular chemist, interested in the synthesizing and studying chemical aggregates on the nanoscale for the development of nanotechnological clusters including niosomes. First, a connectional review of the molecular structure and physicochemical properties of niosome forming non-ionic surfactants and additive agents have been discussed. Second, a systematic survey of niosome preparation and loading methods, administration routes, characterization of niosomes, their toxicity studies and mechanism of drug release; used in recent articles have been performed. Copyright © 2014 Elsevier B.V. All rights reserved.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Pharmaceutics
                Journal ID (iso-abbrev): Pharmaceutics
                Journal ID (publisher-id): pharmaceutics
                Title: Pharmaceutics
                Publisher: MDPI
                ISSN (Electronic): 1999-4923
                Publication date (Electronic): 29 January 2019
                Publication date Collection: February 2019
                Volume: 11
                Issue: 2
                Electronic Location Identifier: 55
                Affiliations
                [1 ]School of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China; gexuemei@ 123456njfu.edu.cn
                [2 ]Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; weiminyan@ 123456sjtu.edu.cn
                [3 ]Department of Pharmaceutical Sciences, Medical College, Henan University of Science and Technology, Luoyang 471023, China; hesuna-2008@ 123456haust.edu.cn
                Author notes
                [* ]Correspondence: yuanweien@ 123456sjtu.edu.cn ; Tel.: +86-21-3420572
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0001-5035-8877
                Article
                Publisher ID: pharmaceutics-11-00055
                DOI: 10.3390/pharmaceutics11020055
                PMC ID: 6410054
                PubMed ID: 30700021
                SO-VID: 8354d505-9f75-468f-bec7-3ff24bbd7936
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 20 December 2018
                Date accepted : 27 January 2019
                Categories
                Subject: Review

                Keywords: niosome,drug delivery,non-ionic surfactant,carrier,stability
                Data availability:
                Keywords: niosome, drug delivery, non-ionic surfactant, carrier, stability

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