Contributors
Yuki Sato: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: VisualizationRole: Writing – original draft
Kazuki Yamaguchi: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Validation
Mikako Ogawa: Role: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: SoftwareRole:
Visualization
Yoh Takekuma: Role: Visualization
Mitsuru Sugawara:
ORCID: https://orcid.org/0000-0001-5350-2950
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SoftwareRole: SupervisionRole: VisualizationRole: Writing – review
& editing
Yu-Hsuan Tsai: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
11
June
2021
Publication date Collection: 2021
Volume: 16
Issue: 6
Electronic Location Identifier: e0253066
Affiliations
[1
]
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
[2
]
Global Station for Biosurfaces and Drug Discovery, Global Institution for Collaborative
Research and Education (GI-CoRE), Hokkaido University, Sapporo, Hokkaido, Japan
[3
]
Department of Pharmacy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
Shenzhen Bay Laboratory, CHINA
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-20-38266
DOI: 10.1371/journal.pone.0253066
PMC ID: 8195392
PubMed ID: 34115818
SO-VID: 835cc300-6119-4bc5-8dd4-72efb878c2a7
Copyright © © 2021 Sato et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 5
December
2020
Date
accepted
: 28
May
2021
Page count
Figures: 4,
Tables: 1,
Pages: 16
Funding
Funded by:
The Japan Society for the Promotion of Sciences
Award ID: 16K00842, 20K07153
Award Recipient
:
Yuki Sato
Funded by:
Grants-in-Aid for Regional R&D Proposal-Based Program from Northern Advancement Center
for Science & Technology of Hokkaido
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5350-2950
Mitsuru Sugawara
Funded by:
Hokkaido University, Global Facility Center (GFC), Pharma Science Open Unit (PSOU),
funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT)
under “Support Program for Implementation of New Equipment Sharing System
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5350-2950
Mitsuru Sugawara
Funded by:
The Platform Project for Supporting in Drug Discovery and Life Science Research (Platform
for Drug Discovery, Informatics, and Structural Life Science) from the MEXT and Japan
Agency for Medical Research and Development (AMED)
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5350-2950
Mitsuru Sugawara
This work was supported in part by Grants-in-Aid for Regional R&D Proposal-Based Program
from Northern Advancement Center for Science & Technology of Hokkaido and Grants-in-Aid
for Scientific Research (C) (Grant number 16K00842, 20K07153) from the Japan Society
for the Promotion of Science (JSPS). This research was partly supported by Hokkaido
University, Global Facility Center (GFC), Pharma Science Open Unit (PSOU), funded
by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) under
“Support Program for Implementation of New Equipment Sharing System.” This research
was also partially supported by the Platform Project for Supporting in Drug Discovery
and Life Science Research (Platform for Drug Discovery, Informatics, and Structural
Life Science) from the MEXT and Japan Agency for Medical Research and Development
(AMED).
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Fluorescence Imaging
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Subject:
Drug Absorption
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Routes of Administration
Subject:
Oral Administration
Subject:
Research and Analysis Methods
Subject:
Biological Cultures
Subject:
Cell Lines
Subject:
Caco-2 Cells
Subject:
Research and Analysis Methods
Subject:
Bioassays and Physiological Analysis
Subject:
Biochemical Analysis
Subject:
Bioelectrochemical Analysis
Subject:
Amperometry
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