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      Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial.

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          Abstract

          Initial results of the ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) comparing neoadjuvant chemoradiotherapy plus surgery versus surgery alone in patients with squamous cell carcinoma and adenocarcinoma of the oesophagus or oesophagogastric junction showed a significant increase in 5-year overall survival in favour of the neoadjuvant chemoradiotherapy plus surgery group after a median of 45 months' follow-up. In this Article, we report the long-term results after a minimum follow-up of 5 years.

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          Author and article information

          Journal
          Lancet Oncol.
          The Lancet. Oncology
          1474-5488
          1470-2045
          Sep 2015
          : 16
          : 9
          Affiliations
          [1 ] Department of Surgery, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands. Electronic address: j.shapiro@erasmusmc.nl.
          [2 ] Department of Surgery, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands; Department of Surgery, Academic Medical Centre, Amsterdam, Netherlands.
          [3 ] Department of Radiation Oncology, Academic Medical Centre, Amsterdam, Netherlands.
          [4 ] Department of Surgery, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands.
          [5 ] Department of Surgery, Academic Medical Centre, Amsterdam, Netherlands.
          [6 ] Department of Medical Oncology, Academic Medical Centre, Amsterdam, Netherlands.
          [7 ] Department of Surgery, Catharina Hospital, Eindhoven, Netherlands.
          [8 ] Department of Medical Oncology, University Medical Centre Groningen, Groningen, Netherlands.
          [9 ] Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
          [10 ] Department of Surgery, VU Medical Centre, Amsterdam, Netherlands.
          [11 ] Department of Medical Oncology, Rijnstate Hospital, Arnhem, Netherlands.
          [12 ] Department of Pathology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands; Department of Pathology, Academic Medical Centre, Amsterdam, Netherlands.
          [13 ] Department of Medical Oncology, Catharina Hospital, Eindhoven, Netherlands.
          [14 ] Department of Medical Oncology, Academic Medical Centre, Amsterdam, Netherlands; Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
          [15 ] Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.
          [16 ] Department of Medical Oncology, VU Medical Centre, Amsterdam, Netherlands.
          [17 ] Department of Surgery, Rijnstate Hospital, Arnhem, Netherlands.
          [18 ] Department of Pathology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands; Department of Pathology, St Lucas Andreas Hospital, Amsterdam, Netherlands.
          [19 ] Department of Radiation Oncology, Catharina Hospital, Eindhoven, Netherlands.
          [20 ] Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; Verbeeten Institute, Tilburg, Netherlands.
          [21 ] Department of Pathology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands.
          [22 ] Department of Radiation Oncology, University Medical Centre Groningen, Groningen, Netherlands.
          [23 ] Department of Radiation Oncology, VU Medical Centre, Amsterdam, Netherlands.
          [24 ] Department of Radiation Oncology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands.
          [25 ] Arnhem Radiotherapeutic Institute ARTI, Arnhem, Netherlands.
          [26 ] Department of Public Health, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands.
          [27 ] Department of Medical Oncology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, Netherlands.
          Article
          S1470-2045(15)00040-6
          10.1016/S1470-2045(15)00040-6
          26254683
          Copyright © 2015 Elsevier Ltd. All rights reserved.

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