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      Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats.

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          Abstract

          In addicts, craving and relapse are frequently induced by the recall of memories related to a drug experience. Several studies have demonstrated that drug-related memories are reactivated after exposure to environmental cues and may undergo reconsolidation, a process that can strengthen memories. Thus, reactivation of mnemonic traces provides an opportunity for disrupting memories that contribute to the pathological cycle of addiction. Here we used drug-induced conditioned place preference (CPP) to investigate whether cannabidiol (CBD), a phytocannabinoid, given just after reactivation sessions, would affect reconsolidation of drug-reward memory, reinstatement of morphine-CPP, or conditioned place aversion precipitated by naltrexone in Wistar rats. We found that CBD impaired the reconsolidation of preference for the environment previously paired with both morphine and cocaine. This disruption seems to be persistent, as the preference did not return after further reinstatement induced by priming drug and stress reinstatement. Moreover, in an established morphine-CPP, an injection of CBD after the exposure to a conditioning session led to a significant reduction of both morphine-CPP and subsequent conditioned place aversion precipitated by naltrexone in the same context. Thus, established memories induced by a drug of abuse can be blocked after reactivation of the drug experience. Taken together, these results provide evidence for the disruptive effect of CBD on reconsolidation of contextual drug-related memories and highlight its therapeutic potential to attenuate contextual memories associated with drugs of abuse and consequently to reduce the risk of relapse.

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          Author and article information

          Journal
          Addict Biol
          Addiction biology
          Wiley-Blackwell
          1369-1600
          1355-6215
          May 2017
          : 22
          : 3
          Affiliations
          [1 ] Laboratory of Psychopharmacology, Department of Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
          Article
          10.1111/adb.12366
          26833888
          83864d8a-51a1-4fb9-b1ed-f102b718ada7
          History

          cannabidiol,conditioned place preference,memory reconsolidation

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