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Tetrodotoxin derivatives in puffer fish.

Author(s): Priscila A M Nakamura, T Yasumoto

Publication date: 1984-12-31

Keywords: Animals, Chemical Phenomena, Chemistry, Fishes, Poisonous, metabolism, Intestines, analysis, Liver, Magnetic Resonance Spectroscopy, Mice, Skin, Spectrometry, Fluorescence, Tetrodotoxin, toxicity

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Abstract

Analysis of puffer fish tissue extracts by a fluorometric tetrodotoxin analyzer revealed the presence of three tetrodotoxin derivatives besides tetrodotoxin. The derivatives were isolated and identified as tetrodonic acid, 4-epitetrodotoxin and anhydrotetrodotoxin on the basis of mass spectral and 1H NMR measurements. The lethal potencies of 4-epitetrodotoxin and anhydrotetrodotoxin to mice by i.p. injection were 710 and 92 mouse units/mg, respectively.

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PubMed ID:: 4024136

ScienceOpen disciplines: Chemistry

Keywords: Animals,Chemical Phenomena,Chemistry,Fishes, Poisonous,metabolism,Intestines,analysis,Liver,Magnetic Resonance Spectroscopy,Mice,Skin,Spectrometry, Fluorescence,Tetrodotoxin,toxicity

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ScienceOpen disciplines: Chemistry

Tetrodotoxin derivatives in puffer fish.

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