7
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Final Height in Patients with Idiopathic Short Stature and High Growth Hormone Responses to Stimulation Tests

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Children with idiopathic short stature (ISS) may have normal or increased growth hormone (GH) responses to provocation tests and achieve a final height (FH) below –2.0 standard deviation score (SDS) if untreated. FH of subjects with high stimulated GH levels has not been studied in detail. Aim: It was the aim of this study to analyse FH in ISS patients with high GH peak responses to the provocation test. Patients and Methods: We studied 16 patients (9 pre-pubertal) with ISS and a GH peak ≧40 mU/l to insulin-induced hypoglycaemia. The patients were recalled at age 19.7 ± 2.5 years for measurement of FH when blood samples were obtained for serum insulin-like growth factor (IGF)-I, IGF binding protein 3, acid-labile subunit and GH binding protein measurements. GH bioactivity was determined using the Nb2 bioassay. Results: FH was –3.1 ± 1.0 SDS, being significantly lower than target height (TH). At FH, IGF-I levels were within –1.5 and +1.5 SDS for age and sex in 10 patients and higher than +1.5 SDS in 6 patients. IGF binding protein 3, acid-labile subunit, GH binding protein levels and GH bioactivity values were normal. Summary: These data suggest that patients with ISS and high GH levels during a GH stimulation test may have a more compromised FH. The association of severe ISS with a peak GH >40 mU/l might suggest a degree of insensitivity for the GH-IGF-I axis.

          Related collections

          Most cited references22

          • Record: found
          • Abstract: not found
          • Article: not found

          Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Standards for children's height at ages 2-9 years allowing for heights of parents.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Growth hormone insensitivity associated with a STAT5b mutation.

                Bookmark

                Author and article information

                Journal
                HRE
                Horm Res Paediatr
                10.1159/issn.1663-2818
                Hormone Research in Paediatrics
                S. Karger AG
                1663-2818
                1663-2826
                2007
                April 2007
                28 November 2006
                : 67
                : 5
                : 224-230
                Affiliations
                Departments of aPaediatrics and bMedicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; cDepartment of Endocrinology, St. Bartholomew’s and The Royal London Hospitals, London, UK
                Article
                97512 Horm Res 2007;67:224–230
                10.1159/000097512
                17135759
                83a1896a-c244-4eb9-887c-9bb9edf3b4b2
                © 2007 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                : 03 July 2006
                : 28 September 2006
                Page count
                Figures: 3, Tables: 1, References: 27, Pages: 7
                Categories
                Original Paper

                Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
                Growth hormone/insulin-like growth factor-I axis,Growth hormone insensitivity,Idiopathic short stature,Growth hormone peak

                Comments

                Comment on this article