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      Effect of a Long-Acting Fluorinated Androgen on Implantation in ‘Delayed’ Mice

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          Abstract

          The effect of fluoxymesterone (FMA), a fluorinated androgen, on ovum implantation has been studied using ovariectomized, progesterone-treated pregnant (‘delayed’) mice. 500 µg FMA, given either continuously from day 4 to 9 or singly on day 8, was able to induce implantation but at the same time caused total resorption of implanted embryos in the case of prolonged treatment with the drug. This anti-estrogenic activity of FMA could be reversed by supplementation of 0.25 µg estradiol-17 β given on day 8. Testosterone also induced implantations in ‘delayed’ mice. FMA and testosterone given to long-term ovariectomized, progesterone-primed mice showed characteristic changes in uterine epithelial cell morphology similar to the attachment found in normal pregnancy. The possible mechanism of action of FMA in early pregnancy will be discussed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1980
          1980
          25 November 2008
          : 12
          : 1
          : 22-31
          Affiliations
          Department of Physiology, All India Institute of Medical Sciences, New Delhi
          Article
          179102 Horm Res 1980;12:22–31
          10.1159/000179102
          7364385
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

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