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      Activation of farnesoid X receptor induces RECK expression in mouse liver.

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          Abstract

          Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor of matrix metalloproteinases, as a novel target gene of FXR in mouse liver. We found that FXR agonist substantially augmented hepatic RECK mRNA and protein expression in vivo and in vitro. FXR regulated the transcription of RECK through directly binding to FXR response element located within intron 1 of the mouse RECK gene. Moreover, FXR agonist reversed the down-regulation of RECK in the livers from mice fed a methionine and choline deficient diet. In summary, our data suggest that RECK is a novel transcriptional target of FXR in mouse liver, and provide clues to better understanding the function of FXR in liver.

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          Author and article information

          Journal
          Biochem. Biophys. Res. Commun.
          Biochemical and biophysical research communications
          Elsevier BV
          1090-2104
          0006-291X
          Jan 03 2014
          : 443
          : 1
          Affiliations
          [1 ] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
          [2 ] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
          [3 ] Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032, China. Electronic address: meilingzhou2012@gmail.com.
          [4 ] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: yhchloech@gmail.com.
          Article
          S0006-291X(13)01984-0
          10.1016/j.bbrc.2013.11.082
          24291500
          83ce25f4-c868-40ea-bb74-3ba5aff65fc8
          History

          Transactivation,farnesoid X receptor,fetal bovine serum,matrix metalloproteinases,methionine and choline deficient,phosphoenolpyruvate carboxykinase,retinoid X receptor α,reversion-inducing cysteine rich protein with Kazal motifs,small heterodimer partner,sterol regulatory element-binding protein-1c,FBS,FXR,Farnesoid X receptor,MCD,MMPs,PEPCK,Primary hepatocytes,RECK,RXRα,SHP,SREBP-1c

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