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Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.
Li Xie
1 ,
Dan Zhu ,
Subhankar Dolai ,
Tao Liang ,
Tairan Qin ,
Youhou Kang ,
Huanli Xie ,
Ya-Chi Huang ,
Herbert Y Gaisano
Jun 2015
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Abstract
Of the four exocytotic syntaxins (Syns), much is now known about the role of Syn-1A (pre-docked secretory granules [SGs]) and Syn-3 (newcomer SGs) in insulin exocytosis. Some work was reported on Syn-4's role in biphasic glucose-stimulated insulin secretion (GSIS), but its precise role in insulin SG exocytosis remains unclear. In this paper we examine this role in human beta cells.