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      Amniotic Fluid, Maternal and Fetal Blood Insulin in Overweight Pregnant Women

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      Hormone Research in Paediatrics

      S. Karger AG

      Weight gain, Insulin, Amniotic fluid, Pregnancy

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          The effect of excessive maternal weight gain on insulin levels during pregnancy (15 cases) was compared with the insulin levels in a control group (20 normal pregnancies) by radio immunologic determination of insulin in the amniotic fluid and in maternal and fetal blood. The mean values of insulin in the control group were as follows: mother 24.9 ± 0.51, fetus 10.86 ± 0.48 and amniotic fluid 6.08 ± 0.42 µU/ml, and in patients with excessive weight gain during pregnancy, maternal insulin mean values were 39.45 ± 1.86, fetal 20.99 ± 3.39 and amniotic fluid 12.25 ± 1.15 µU/ml. Insulin concentrations in maternal blood (P < 0.001), fetal blood (P < 0.001) and amniotic fluid (P < 0.001) were higher in excessive weight gain pregnancies as compared to the control group.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 9
          : 5
          : 249-253
          Department of Endocrinology, Medical College of Georgia, Augusta, Ga., and 1st Department of Obstetrics and Gynecology, University of Athens, Athens
          178920 Horm Res 1978;9:249–253
          © 1978 S. Karger AG, Basel

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          Pages: 5


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