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      Individual Differences in Pain: Understanding the Mosaic that Makes Pain Personal

      research-article
      , PhD
      Pain

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          Abstract

          The experience of pain is characterized by tremendous inter-individual variability. Multiple biological and psychosocial variables contribute to these individual differences in pain, including demographic variables, genetic factors, and psychosocial processes. For example, sex, age and ethnic group differences in the prevalence of chronic pain conditions have been widely reported. Moreover, these demographic factors have been associated with responses to experimentally-induced pain. Similarly, both genetic and psychosocial factors contribute to clinical and experimental pain responses. Importantly, these different biopsychosocial influences interact with each other in complex ways to sculpt the experience of pain. Some genetic associations with pain have been found to vary across sex and ethnic group. Moreover, genetic factors also interact with psychosocial factors, including stress and pain catastrophizing, to influence pain. The individual and combined influences of these biological and psychosocial variables results in a unique mosaic of factors that contributes pain in each individual. Understanding these mosaics is critically important in order to provide optimal pain treatment, and future research to further elucidate the nature of these biopsychosocial interactions is needed in order to provide more informed and personalized pain care.

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          Author and article information

          Journal
          7508686
          6347
          Pain
          Pain
          Pain
          0304-3959
          1872-6623
          19 November 2016
          April 2017
          01 April 2018
          : 158
          : Suppl 1
          : S11-S18
          Affiliations
          University of Florida College of Dentistry and Pain Research & Intervention Center of Excellence
          Author notes
          Roger B. Fillingim, PhD, University of Florida, 2004 Mowry Road, PO Box 100404, Gainesville, FL, USA 32610-0404, Phone: 352-273-5963, FAX: 352-273-5985, rfilling@ 123456ufl.edu
          Article
          PMC5350021 PMC5350021 5350021 nihpa830843
          10.1097/j.pain.0000000000000775
          5350021
          27902569
          83f97ebc-dc4c-4c75-b7d6-80ab12b2e3d0
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