Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade.

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Abstract

Most patients with hepatocellular carcinoma (HCC) have associated chronic liver disease, the severity of which is currently assessed by the Child-Pugh (C-P) grade. In this international collaboration, we identify objective measures of liver function/dysfunction that independently influence survival in patients with HCC and then combine these into a model that could be compared with the conventional C-P grade.

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Journal

Journal ID (iso-abbrev): J. Clin. Oncol.

Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology

ISSN (Electronic): 1527-7755

ISSN (Print): 0732-183X

Publication date (Electronic): Feb 20 2015

Volume: 33

Issue: 6

Affiliations

[1 ] Philip J. Johnson, Sarah Berhane, and Daniel Palmer, University of Liverpool, Liverpool; Philip J. Johnson and Daniel Palmer, The Clatterbridge Cancer Centre National Health Service (NHS) Foundation Trust, Bebington; Mabel Teng, Addenbrooke's Hospital, University of Cambridge, Cambridge; Helen L. Reeves, Northern Institute for Cancer Research and the Hepatopancreatobiliary Multidisciplinary Team, Newcastle upon Tyne NHS Foundation Trust, The Freeman Hospital, Newcastle upon Tyne; James O'Beirne, The Sheila Sherlock Liver Centre, Royal Free Hospital, London; Richard Fox and Anna Skowronska, School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; Chiaki Kagebayashi and Shinji Satomura, Wako Life Sciences, Mountain View, CA; Rebecca Miksad, Beth Israel Deaconess Medical Center, Institute for Technology Assessment, Massachusetts General Hospital, and Harvard Medical School, Boston, MA; Winnie Yeo, Frankie Mo, and Stephen L. Chan, State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, Chinese University of Hong Kong, Hong Kong Cancer Institute; Paul Lai, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China; Mercedes Iñarrairaegui and Bruno Sangro, Clinica Universidad de Navarra, and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, Pamplona, Spain; Toshifumi Tada, Takashi Kumada, and Hidenori Toyoda, Ogaki Municipal Hospital, Ogaki, Gifu, Japan. Philip.Johnson@liverpool.ac.uk.

[2 ] Philip J. Johnson, Sarah Berhane, and Daniel Palmer, University of Liverpool, Liverpool; Philip J. Johnson and Daniel Palmer, The Clatterbridge Cancer Centre National Health Service (NHS) Foundation Trust, Bebington; Mabel Teng, Addenbrooke's Hospital, University of Cambridge, Cambridge; Helen L. Reeves, Northern Institute for Cancer Research and the Hepatopancreatobiliary Multidisciplinary Team, Newcastle upon Tyne NHS Foundation Trust, The Freeman Hospital, Newcastle upon Tyne; James O'Beirne, The Sheila Sherlock Liver Centre, Royal Free Hospital, London; Richard Fox and Anna Skowronska, School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; Chiaki Kagebayashi and Shinji Satomura, Wako Life Sciences, Mountain View, CA; Rebecca Miksad, Beth Israel Deaconess Medical Center, Institute for Technology Assessment, Massachusetts General Hospital, and Harvard Medical School, Boston, MA; Winnie Yeo, Frankie Mo, and Stephen L. Chan, State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, Chinese University of Hong Kong, Hong Kong Cancer Institute; Paul Lai, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China; Mercedes Iñarrairaegui and Bruno Sangro, Clinica Universidad de Navarra, and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas, Pamplona, Spain; Toshifumi Tada, Takashi Kumada, and Hidenori Toyoda, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.

Article

Publisher Item ID: JCO.2014.57.9151

DOI: 10.1200/JCO.2014.57.9151

PubMed ID: 25512453

SO-VID: 840cf461-0950-4d5b-9f3d-fbcb3f1f0984

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