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      Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model.

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          Abstract

          We have reported that levetiracetam, a novel anticonvulsant with analgesic properties, synergizes with ibuprofen/aspirin/paracetamol in a model of diabetic painful neuropathy (DPN). Most guidelines recommend gabapentin, pregabalin, and duloxetine as first- or second-line agents for DPN.

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          Author and article information

          Journal
          Psychopharmacology (Berl.)
          Psychopharmacology
          Springer Nature
          1432-2072
          0033-3158
          Jun 2017
          : 234
          : 11
          Affiliations
          [1 ] Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe, 450, POB 146, Belgrade, 11221, Serbia. racabbr@eunet.rs.
          [2 ] Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe, 450, POB 146, Belgrade, 11221, Serbia.
          Article
          10.1007/s00213-017-4583-z
          10.1007/s00213-017-4583-z
          28332005
          840f684c-ada2-47b1-a5c3-c0c089a5152f

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