Effects of deep heating to treat osteoarthritis pain: systematic review

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Abstract

ABSTRACT BACKGROUND AND OBJECTIVES: Osteoarthritis is an inflammatory and degenerative joint disease, causing pain, musculoskeletal disorders and impact on functionality, daily life activities and quality of life. The action of physical agents by means of deep heating seems to be an alternative to treat such disease. This study aimed at verifying the effects of deep heating on osteoarthritis patients. CONTENTS: A systematic review was carried out in Medline, Scielo and LILACS databases as from keywords "Osteoarthritis", "Induced Hyperthermia", "Physiotherapy" and "Ultrasound", and other keywords such as "Deep heat", "Microwaves" and Short-waves", in Portuguese, English and Spanish, in the period from January 2005 to January 2016, and 986 articles were found. Initially, 16 potentially relevant articles were selected for the study and, after a judicious qualitative analysis, nine complete articles meeting inclusion criteria were selected. CONCLUSION: Physical deep heating physical agents (ultrasound, short-waves diathermy and microwaves) were beneficial to manage pain and other variables in individuals with osteoarthritis in different levels of severity, especially in the long term. However, these effects are better observed when applied simultaneously with kinesiotherapy.

Translated abstract

RESUMO JUSTIFICATIVA E OBJETIVOS: A osteoartrite é uma doença articular inflamatória e degenerativa, que provoca dor, agravos osteoarticulares e impacto na funcionalidade, nas atividades de vida diária e na qualidade de vida. A ação de agentes físicos por meio do calor profundo parece ser uma alternativa no tratamento dessa doença. O objetivo deste estudo foi verificar os efeitos do calor profundo em indivíduos com osteoartrite. CONTEÚDO: Realizou-se uma revisão sistemática nas bases de dados Medline, Scielo e LILACS, a partir dos descritores "Osteoartrite", "Hipertermia Induzida", "Fisioterapia" e "Ultrassom" e outras palavras-chaves como "Calor profundo", "Micro-ondas" e "Ondas curtas", nas línguas portuguesa, inglesa e espanhola, no período de janeiro de 2005 a janeiro de 2016. Encontraram-se 986 artigos. Inicialmente, 16 artigos potencialmente relevantes foram selecionados para o estudo, e, após uma análise qualitativa criteriosa, selecionaram-se 9 artigos completos que preencheram os critérios de inclusão exigidos. CONCLUSÃO: Os agentes físicos em forma de calor profundo (ultrassom, diatermia por ondas curtas e micro-ondas) ofertam benefícios no manuseio da dor e outras variáveis em indivíduos com osteoartrite em diferentes graus de acometimento, especialmente no longo prazo. Contudo, esses efeitos são mais bem observados quando aplicados em concomitância à cinesioterapia.

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Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Dong Hyun Sohn, Jeremy Sokolove, Orr Sharpe … (2012)

Introduction Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises is unclear, but proteins in the synovial fluid of affected joints could conceivably contribute. We therefore surveyed the proteins present in OA synovial fluid and assessed their immunostimulatory properties. Methods We used mass spectrometry to survey the proteins present in the synovial fluid of patients with knee OA. We used a multiplex bead-based immunoassay to measure levels of inflammatory cytokines in serum and synovial fluid from patients with knee OA and from patients with rheumatoid arthritis (RA), as well as in sera from healthy individuals. Significant differences in cytokine levels between groups were determined by significance analysis of microarrays, and relations were determined by unsupervised hierarchic clustering. To assess the immunostimulatory properties of a subset of the identified proteins, we tested the proteins' ability to induce the production of inflammatory cytokines by macrophages. For proteins found to be stimulatory, the macrophage stimulation assays were repeated by using Toll-like receptor 4 (TLR4)-deficient macrophages. Results We identified 108 proteins in OA synovial fluid, including plasma proteins, serine protease inhibitors, proteins indicative of cartilage turnover, and proteins involved in inflammation and immunity. Multiplex cytokine analysis revealed that levels of several inflammatory cytokines were significantly higher in OA sera than in normal sera, and levels of inflammatory cytokines in synovial fluid and serum were, as expected, higher in RA samples than in OA samples. As much as 36% of the proteins identified in OA synovial fluid were plasma proteins. Testing a subset of these plasma proteins in macrophage stimulation assays, we found that Gc-globulin, α1-microglobulin, and α2-macroglobulin can signal via TLR4 to induce macrophage production of inflammatory cytokines implicated in OA. Conclusions Our findings suggest that plasma proteins present in OA synovial fluid, whether through exudation from plasma or production by synovial tissues, could contribute to low-grade inflammation in OA by functioning as so-called damage-associated molecular patterns in the synovial joint.

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Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study.

S Muraki, T Akune, H Oka … (2010)

Knee osteoarthritis (OA) is a major public health issue causing chronic pain and disability. However, there is little information on the impact of this disease on quality of life (QOL) in Japanese men and women. The objective of the present study was to clarify the impact of radiographic and symptomatic knee OA on QOL in Japan. This study examined the association of radiographic and symptomatic knee OA with QOL parameters such as the Medical Outcomes Study Short Form-8 (SF-8), EuroQOL (EQ-5D) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Radiographic knee OA was defined according to Kellgren/Lawrence (KL) grades, and symptomatic knee OA was defined as KL=3 or 4 with knee pain. We also examined the independent association of symptomatic knee OA and grip strength with QOL. From the 3040 participants in the Research on Osteoarthritis Against Disability (ROAD) study, the present study analyzed 2126 subjects older than 40 years who completed the questionnaires (767 men and 1359 women; mean age, 68.9+/-10.9 years). Subjects with KL=3 or 4 had significantly lower physical QOL as measured by the physical component summary (PCS) score of the SF-8 and pain domains of the WOMAC, whereas mental QOL, as measured by the mental component summary (MCS) score of the SF-8, was higher in subjects with KL=3 or 4 than KL=0 or 1. Symptomatic knee OA was significantly more likely than radiographic knee OA without pain to be associated with physical QOL loss as measured by the PCS score and physical domains of the WOMAC. Symptomatic knee OA and grip strength were independently associated with physical QOL. This cross-sectional study revealed that subjects with symptomatic knee OA had significantly lower physical QOL than subjects without it. Copyright 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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Risk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study.

Henrik T Sørensen, Joseph K. McLaughlin, T. S. Johnsen … (2005)

It remains uncertain if the excess cardiovascular risk of rofecoxib and celecoxib reported in clinical trials is present in routine practice and whether the use of other nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) also carries an increased cardiovascular risk. We performed a population-based case-control study to examine the risk of myocardial infarction (MI) among users of various categories of nonaspirin NSAIDs. Using data from hospital discharge registries in the counties of North Jutland, Viborg, and Aarhus, Denmark, and the Danish Civil Registration System, we identified 10,280 cases of first-time hospitalization for MI and 102,797 sex- and age-matched non-MI population controls. All prescriptions for nonaspirin NSAIDs filled before the date of admission for MI were identified using population-based prescription databases. Relative risk estimates for MI were adjusted for a history of cardiovascular disease, hypertension, diabetes mellitus, chronic bronchitis or emphysema, alcoholism, liver cirrhosis, upper gastrointestinal bleeding, rheumatoid arthritis, systemic lupus erythematosus and the use of high-dose aspirin, platelet inhibitors, insulin or oral hypoglycemic drugs, antihypertensive drugs, lipid-lowering drugs, oral anticoagulants, nitrates, penicillamine, gold, oral glucocorticoids, and hormone therapy before the date of admission for MI. Current users of rofecoxib had an elevated risk estimate for hospitalization for MI compared with nonusers of any category of nonaspirin NSAIDs (adjusted relative risk [ARR], 1.80; 95% confidence interval [CI], 1.47-2.21). Increased risk estimates were also found among current users of celecoxib (ARR, 1.25; 95% CI, 0.97-1.62), other cyclooxygenase-2 selective inhibitors (ARR, 1.45; 95% CI, 1.09-1.93), naproxen (ARR, 1.50; 95% CI, 0.99-2.29), and other conventional nonaspirin NSAIDs (ARR, 1.68; 95% CI, 1.52-1.85). The highest ARRs were found among new users of all examined drug categories. Current and new users of all classes of nonaspirin NSAIDs had elevated relative risk estimates for MI. Although the increased risk estimates may partly reflect unmeasured bias, they indicate the need for further examination of the cardiovascular safety of all nonaspirin NSAIDs.

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Author and article information

Contributors

Matheus Santos Gomes Jorge: Role: ND

Caroline Zanin: Role: ND

Bruna Knob: Role: ND

Lia Mara Wibelinger: Role: ND

Journal

Journal ID (publisher-id): rdor

Title: Revista Dor

Abbreviated Title: Rev. dor

Publisher: Sociedade Brasileira para o Estudo da Dor (São Paulo, SP, Brazil )

ISSN (Print): 1806-0013

ISSN (Electronic): 2317-6393

Publication date (Print and electronic): March 2017

Volume: 18

Issue: 1

Pages: 79-84

Affiliations

[2] São Jorge Rio Grande do Sul orgnameUniversidade de Passo Fundo orgdiv1Faculdade de Educação Física e Fisioterapia Brazil

[1] Soledade Rio Grande do Sul orgnameUniversidade de Passo Fundo orgdiv1Faculdade de Educação Física e Fisioterapia Brazil

[3] Chapada Rio Grande do Sul orgnameUniversidade de Passo Fundo orgdiv1Faculdade de Educação Física e Fisioterapia Brazil

[4] Passo Fundo Rio Grande do Sul orgnameUniversidade de Passo Fundo orgdiv1Faculdade de Educação Física e Fisioterapia Brazil

Article

Publisher ID: S1806-00132017000100079

DOI: 10.5935/1806-0013.20170016

SO-VID: 8416c7e1-e276-420b-93ad-b677382f5508

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This work is licensed under a Creative Commons Attribution 4.0 International License.

History

Date received : 14 July 2016

Date accepted : 20 January 2017

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Figures: 0, Tables: 0, Equations: 0, References: 26, Pages: 6

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SciELO Brazil

Keywords: Dor,Fisioterapia,Hipertermia induzida,Osteoa rtrite,Ultrassom,Induced hyperthermia,Osteoarthritis,Pain,Physiotherapy,Ultrasound

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Keywords: Dor, Fisioterapia, Hipertermia induzida, Osteoa rtrite, Ultrassom, Induced hyperthermia, Osteoarthritis, Pain, Physiotherapy, Ultrasound

Effects of deep heating to treat osteoarthritis pain: systematic review Translated title: Efeitos do calor profundo no tratamento da dor na osteoartrite: revisão sistemática

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Most cited references 23

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan: the ROAD study.

Risk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study.

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