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      Comorbid Depression and Platelet Serotonin in Hemodialysis Patients

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          Background/Aim: Comorbid depression often occurs in chronic renal failure patients on hemodialysis (HD). Reduced serotonin (5-HT) function is implicated in the pathophysiology of depression. Methods: Comorbid depression and different clusters of depressive symptoms were assessed in 79 male HD patients and 35 male depressed psychiatric patients. Platelet 5-HT concentration (a peripheral model for the central serotonergic neurons) was determined in all patients and 80 male healthy controls. Results: Comorbid depression occurred in 50 out of 79 HD patients. Depressed psychiatric patients and depressed HD patients had higher scores of anxiety, retardation, and cognitive symptoms than nondepressed HD patients. Platelet 5-HT concentration was lower in depressed or nondepressed HD patients than in healthy controls, or in depressed patients. Higher platelet 5-HT content was found in depressed psychiatric patients with depressive clusters than in all other patients. Among HD patients, anxious HD patients had a higher platelet 5-HT concentration than HD patients without anxiety symptoms. Conclusions: Comorbid depression occurred in 63% of HD patients. Dialyzed patients had decreased platelet 5-HT concentration, regardless of the occurrence of comorbid depression. Higher platelet 5-HT concentration was related to anxiety symptoms in HD patients. Our data suggest that platelet 5-HT concentration might be a suitable marker for anxiety symptoms in dialyzed patients.

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          Most cited references 8

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          Depression in patients with chronic renal disease

           Paul L Kimmel (2002)
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            Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression.

             D Mück-Seler (1996)
            Platelet 5-HT concentrations were determined in 84 male and 82 female psychotic and non-psychotic depressed inpatients with various degrees of suicidal behaviour, and in 175 healthy controls. Psychotic patients had higher platelet 5-HT concentrations than non-psychotic depressed patients and healthy controls. A sex difference, i.e., lower platelet 5-HT concentrations in females was found in healthy controls, depressed patients, non-psychotic patients and non-suicidal depressed patients. A negative relationship was shown between platelet 5-HT concentrations and suicidal behaviour. The lowest platelet 5-HT concentrations were associated with the most pronounced suicidal behaviour (with suicidal attempts and with the acts of suicide). The results suggest that the differences in platelet 5-HT concentrations found in depressed patients might be used as a biological marker for suicidal behaviour.
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              Platelet 5-HT concentration and comorbid depression in war veterans with and without posttraumatic stress disorder


                Author and article information

                Nephron Clin Pract
                Nephron Clinical Practice
                S. Karger AG
                January 2004
                17 November 2004
                : 96
                : 1
                : c10-c14
                aDepartment of Urology, Dialysis Center, University Hospital Center Zagreb, bDivision of Molecular Medicine, Rudjer Bošković Institute, and cDepartment of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
                75566 Nephron Clin Pract 2004;96:c10–c14
                © 2004 S. Karger AG, Basel

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                Tables: 3, References: 25, Pages: 1
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