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Abstract
To compare long-term fluctuation of blue-on-yellow automated perimetry with white-on-white
automated perimetry in normal subjects.
White-on-white and blue-on-yellow automated perimetry were performed on a Humphrey
Visual Field Analyzer and an Octopus perimeter, both modified for blue-on-yellow perimetry.
The study sample consisted of 31 eyes of 31 normal subjects for the Humphrey perimeter
and 33 eyes of 33 normal subjects for the Octopus perimeter. After one practice session,
each subject completed four testing sessions over a period of 2 to 8 weeks, each separated
by at least 1 day. Each testing session consisted of both white-on-white and blue-on-yellow
perimetry performed on one eye; the order of the tests was alternated for successive
sessions. Long-term fluctuation (expressed as statistical variance) was calculated
for each test location. Intersubject variability (expressed as statistical variance)
across all subjects was determined for each test location.
On the Humphrey perimeter, the long term fluctuation for blue-on-yellow perimetry
(4.07 +/- 3.07 dB2) was significantly greater than that for white-on-white perimetry
(1.97 +/- 0.99 dB2; P < .001). Long-term fluctuation increased as a function of eccentricity
for both blue-on-yellow and white-on-white perimetry. Short-term fluctuation was significantly
greater for blue-on-yellow (0.46 +/- 0.25 dB) than that for white-on-white perimetry
(0.29 +/- 0.19 dB; P < .02). Finally, the intersubject variability was significantly
greater in blue-on-yellow (13.2 +/- 2.8 dB2) than it was in white-on-white perimetry
(4.25 +/- 1.13 dB2; P < .001). Similar results were found with the Octopus perimeter.
Long-term fluctuation and short-term fluctuation of blue-on-yellow perimetry are greater
than those of white-on-white perimetry in normal subjects. The increased long-term
fluctuation requires appropriate statistical approaches when evaluating serial change
of blue-on-yellow perimetry.