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      Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer.

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          Abstract

          Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel pharmacological target for hypercholesterolemia and associated cardiovascular diseases owing to its function to mediate the degradation of low-density lipoprotein receptor (LDLR). Findings over the past two decades have identified novel binding partners and cellular functions of PCSK9. Notably, PCSK9 is aberrantly expressed in a broad spectrum of cancers and apparently contributes to disease prognosis, indicating that PCSK9 could be a valuable cancer biomarker. Experimental studies demonstrate the contribution of PCSK9 in various aspects of cancer, including cell proliferation, apoptosis, invasion, metastasis, anti-tumor immunity and radioresistance, strengthening the idea that PCSK9 could be a promising therapeutic target. Here, we comprehensively review the involvement of PCSK9 in cancer, summarizing its aberrant expression, association with disease prognosis, biological functions and underlying mechanisms in various malignancies. Besides, we highlight the potential of PCSK9 as a future therapeutic target in personalized cancer medicine.

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          Author and article information

          Journal
          Biochim Biophys Acta Rev Cancer
          Biochimica et biophysica acta. Reviews on cancer
          Elsevier BV
          1879-2561
          0304-419X
          August 2021
          : 1876
          : 1
          Affiliations
          [1 ] School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
          [2 ] School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address: koel@smst.iitkgp.ac.in.
          [3 ] School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address: pcshukla@smst.iitkgp.ac.in.
          Article
          S0304-419X(21)00078-0
          10.1016/j.bbcan.2021.188581
          34144130
          8455ad70-6436-4ae6-843d-6526bbf0d0e9
          History

          PCSK9,Targeted therapy,Anti-tumor immunity,Apoptosis,Metastasis,Cancer

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