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      Simulating leaky integrate and fire neuron with integers

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          Abstract

          The leaky integrate and fire (LIF) neuron represents standard neuronal model used for numerical simulations. The leakage is implemented in the model as exponential decay of trans-membrane voltage towards its resting value. This makes inevitable the usage of machine floating point numbers in the course of simulation. It is known that machine floating point arithmetic is subjected to small inaccuracies, which prevent from exact comparison of floating point quantities. In particular, it is incorrect to decide whether two separate in time states of a simulated system composed of LIF neurons are exactly identical. However, decision of this type is necessary, e.g. to figure periodic dynamical regimes in a reverberating network. Here we offer a simulation paradigm of a LIF neuron, in which neuronal states are described by whole numbers. Within this paradigm, the LIF neuron behaves exactly the same way as does the standard floating point simulated LIF, although exact comparison of states becomes correctly defined.

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          A review of the integrate-and-fire neuron model: I. Homogeneous synaptic input.

          A Burkitt (2006)
          The integrate-and-fire neuron model is one of the most widely used models for analyzing the behavior of neural systems. It describes the membrane potential of a neuron in terms of the synaptic inputs and the injected current that it receives. An action potential (spike) is generated when the membrane potential reaches a threshold, but the actual changes associated with the membrane voltage and conductances driving the action potential do not form part of the model. The synaptic inputs to the neuron are considered to be stochastic and are described as a temporally homogeneous Poisson process. Methods and results for both current synapses and conductance synapses are examined in the diffusion approximation, where the individual contributions to the postsynaptic potential are small. The focus of this review is upon the mathematical techniques that give the time distribution of output spikes, namely stochastic differential equations and the Fokker-Planck equation. The integrate-and-fire neuron model has become established as a canonical model for the description of spiking neurons because it is capable of being analyzed mathematically while at the same time being sufficiently complex to capture many of the essential features of neural processing. A number of variations of the model are discussed, together with the relationship with the Hodgkin-Huxley neuron model and the comparison with electrophysiological data. A brief overview is given of two issues in neural information processing that the integrate-and-fire neuron model has contributed to - the irregular nature of spiking in cortical neurons and neural gain modulation.
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            Dynamics of Encoding in a Population of Neurons

            A simple encoder model, which is a reasonable idealization from known electrophysiological properties, yields a population in which the variation of the firing rate with time is a perfect replica of the shape of the input stimulus. A population of noise-free encoders which depart even slightly from the simple model yield a very much degraded copy of the input stimulus. The presence of noise improves the performance of such a population. The firing rate of a population of neurons is related to the firing rate of a single member in a subtle way.
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              A review of the integrate-and-fire neuron model: II. Inhomogeneous synaptic input and network properties.

              A Burkitt (2006)
              The integrate-and-fire neuron model describes the state of a neuron in terms of its membrane potential, which is determined by the synaptic inputs and the injected current that the neuron receives. When the membrane potential reaches a threshold, an action potential (spike) is generated. This review considers the model in which the synaptic input varies periodically and is described by an inhomogeneous Poisson process, with both current and conductance synapses. The focus is on the mathematical methods that allow the output spike distribution to be analyzed, including first passage time methods and the Fokker-Planck equation. Recent interest in the response of neurons to periodic input has in part arisen from the study of stochastic resonance, which is the noise-induced enhancement of the signal-to-noise ratio. Networks of integrate-and-fire neurons behave in a wide variety of ways and have been used to model a variety of neural, physiological, and psychological phenomena. The properties of the integrate-and-fire neuron model with synaptic input described as a temporally homogeneous Poisson process are reviewed in an accompanying paper (Burkitt in Biol Cybern, 2006).
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                Author and article information

                Journal
                1505.06603

                Neurosciences
                Neurosciences

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