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      Efecto de l-carnitina sobre el peso, niveles de triglicéridos y colesterol de ratones sometidos a dietas normo e hipercalóricas Translated title: EFFECT OF L-CARNITINE ON WEIGHT, CHOLESTEROL AND TRIGLYCERIDES LEVELS OF MICE RECEIVING NORMAL AND HIGH CALORIC DIETS

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          Abstract

          Se llevó a cabo un estudio experimental para determinar el efecto de la L-carnitina sobre el peso y los niveles de lípidos séricos (triglicéridos y colesterol total) en ratones NMRI. Para ello, se condujo un ensayo con arreglo factorial de tratamientos 22 bajo un diseño completamente aleatorizado. Los factores considerados fueron la dieta (normo e hipercalórica) y la incorporación o no de la L-carnitina como suplemento. Esta fue suministrada por vía oral a razón de 2 mg/día. Se evaluaron el peso [g], las concentraciones séricas de triglicéridos [mg·dL-1] y colesterol total [mg·dL-1]. Se aplicó el análisis de varianza y la prueba de comparaciones de medias de Tukey. No se encontraron diferencias significativas entre el tipo de dieta para el peso (F = 4,00; p = 0,0575) y colesterol (F = 0,09; p = 0,7722), ni para la administración de L-carnitina para el peso (F = 1,08; p = 0,3096) y colesterol (F = 0,13; p = 0,7255). En cuanto a los triglicéridos, se encontraron diferencias significativas entre el tipo de dieta (F = 12,73; p = 0,0016) e interacción significativa entre el tipo de dieta y la administración de L-carnitina (F = 5,95; p = 0,0228). Este efecto sugiere que el aminoácido combinado con una dieta baja en calorías podría considerarse como una alternativa para tratar casos de hipertrigliceridemias.

          Translated abstract

          An experimental study was conducted to determine the effect of L-carnitine on weight and serum lipid levels (triglycerides and total cholesterol) on NMRI mice. To do so, a factorial arrangement of treatments 22 under a completely randomized design was carried out. Factors considered were the diet (normal and hypercaloric) and the inclusion or not of the L-carnitine supplement. L-carnitine was orally administered at a rate of 2 mg/day. Weight [g], serum triglyceride concentrations [mg·dL-1] and total cholesterol [mg·dL-1] were evaluated. Analysis of variance test and Tukey mean comparisons were applied. Non significant differences were found between the type of diet for weight (F = 4.00; p = 0.0575), and cholesterol (F = 0.09; p = 0.7722), or for the administration of L-carnitine for the weight (F = 1.08; p = 0.3096), and cholesterol (F = 0.13; p = 0.7255). For triglycerides, significant differences between the type of diet (F = 12.73; p = 0.0016), and significant interaction between type of diet and the administration of L-carnitine (F = 5.95; p = 0.0228), were found. This effect suggests that the amino acid combined with a low calorie diet could be considered as an alternative to treat cases of hypertriglyceridemia.

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          New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.

          In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation, and in the regulation of the mitochondrial acetyl-CoA/CoASH ratio. Interest in these vital metabolic roles of carnitine in skeletal muscle appears to have waned over the past 25 years. However, recent research has shed new light on the importance of carnitine as a regulator of muscle fuel selection. It has been established that muscle free carnitine availability may be limiting to fat oxidation during high intensity submaximal exercise. Furthermore, increasing muscle total carnitine content in resting healthy humans (via insulin-mediated stimulation of muscle carnitine transport) reduces muscle glycolysis, increases glycogen storage and is accompanied by an apparent increase in fat oxidation. By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been established that PDC flux and acetyl group availability limits aerobic ATP re-synthesis at the onset of exercise (the acetyl group deficit). Thus, carnitine plays a vital role in the regulation of muscle fuel metabolism. The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound.
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            Enzymology of the carnitine biosynthesis pathway.

            The water-soluble zwitterion carnitine is an essential metabolite in eukaryotes required for fatty acid oxidation as it functions as a carrier during transfer of activated acyl and acetyl groups across intracellular membranes. Most eukaryotes are able to synthesize carnitine endogenously, besides their capacity to take up carnitine from the diet or extracellular medium through plasma membrane transporters. This review discusses the current knowledge on carnitine homeostasis with special emphasis on the enzymology of the four steps of the carnitine biosynthesis pathway.
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              Effects of L-carnitine on growth performance, carcass composition, and metabolism of lipids in male broilers.

              We studied the effects of L-carnitine on growth performance, carcass composition, and lipid metabolism in male broilers. Six hundred male commercial broilers were allotted to five groups, each of which included three replicates (40 birds per replicate). The groups received the same basal diet supplemented with 0, 25, 50, 75, or 100 mg/kg L-carnitine, respectively. The feeding trial showed that L-carnitine had no significant effect on daily gain or feed conversion. Supplementation with L-carnitine (above 25 mg/kg) in the diet increased breast muscle yield (P < 0.05) and crude fat content of the muscles and decreased abdominal fat content (P < 0.05). Addition of 50, 75, or 100 mg/kg L-carnitine to the diet decreased total activities of glucose-6-phosphate dehydrogenase, malic dehydrogenase, isocitrate dehydrogenase, and lipoprotein lipase (P < 0.05) in the subcutaneous fat and total activity of carnitine palmitoyltransferase-I (P < 0.05) in breast muscles. The results of this study indicate that L-carnitine could reduce the deposit of subcutaneous fat by decreasing total activities of enzymes in the fat and enhance intramuscular fat by decreasing the activity of carnitine palmitoyltransferase-I in breast muscles.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                saber
                Saber
                Saber
                Universidad de Oriente (Cumaná, Sucre, Venezuela )
                1315-0162
                2343-6468
                December 2016
                : 28
                : 4
                : 744-749
                Affiliations
                [01] orgnameInstituto de Investigaciones Biomédicas Francisco Javier Triana Alonso
                [03] orgnameUniversidad de Carabobo orgdiv1Escuela de Bioanálisis orgdiv2Departamento de Ciencias Básicas
                [04] Maracay orgnameUniversidad de Carabobo orgdiv1Escuela de Medicina orgdiv2, Departamento de Farmacología y Fisiopatología Venezuela lmpy2005@ 123456gmail.com
                [02] orgnameUniversidad de Carabobo orgdiv1Escuela de Medicina orgdiv2Departamento de Fisiología y Bioquímica
                Article
                S1315-01622016000400009
                845e6a6c-044b-4560-87d9-9a6a350fc299

                http://creativecommons.org/licenses/by/4.0/

                History
                : September 2016
                : May 2016
                : April 2016
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 16, Pages: 6
                Product

                SciELO Venezuela


                dislipidemia,Amino acid,dyslipidemia,nutritional supplement,Aminoácido,suplemento nutricional

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